7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Base Information

Chemical Name:7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS No.:64500-18-1
Molecular Formula:C9H7ClN2O
Molecular Weight:194.62
Hs Code.:
DSSTox Substance ID:DTXSID80494761
Wikidata:Q82342371
Mol file:64500-18-1.mol

Synonyms:7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;64500-18-1;7-CHLORO-2-METHYLPYRIDO[1,2-A]PYRIMIDIN-4-ONE;DTXSID80494761;AKOS006241600

Suppliers and Price of 7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Chemical Property:

PSA：34.37000
LogP:1.65630
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:194.0246905
Heavy Atom Count:13
Complexity:390

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=O)N2C=C(C=CC2=N1)Cl

Technology Process of 7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

There total 8 articles about 7-Chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1072-98-6
5-chloro-2-pyridylamine

: 105-45-3
acetoacetic acid methyl ester

: 64500-18-1
7-chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: With bismuth(III) chloride; at 100 ℃; for 3h; Green chemistry;
DOI:10.1002/ejoc.201500227

Reference yield: 87.0%

: 1072-98-6
5-chloro-2-pyridylamine

: 141-97-9
ethyl acetoacetate

: 64500-18-1
7-chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: In ethylene glycol; at 100 ℃; for 4h; Green chemistry;
DOI:10.1016/j.tetlet.2020.152269

Reference yield: 81.0%

: 1072-98-6
5-chloro-2-pyridylamine

: 4341-76-8
Ethyl 2-butynoate

: 64500-18-1
7-chloro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Guidance literature:: With silver trifluoromethane sulfate; In chlorobenzene; at 120 ℃; for 24h; regioselective reaction;
DOI:10.1016/j.tetlet.2016.11.079