diethyl [2-(2-nitrophenyl)ethyl]propanedioate

Base Information

• Chemical Name: diethyl [2-(2-nitrophenyl)ethyl]propanedioate
• CAS No.: 5345-19-7
• Molecular Formula: C15H19NO6
• Molecular Weight: 309.319
• Mol file: 5345-19-7.mol

Synonyms:

Chemical Property of diethyl [2-(2-nitrophenyl)ethyl]propanedioate

Chemical Property:

• Vapor Pressure: 2.35E-07mmHg at 25°C
• Boiling Point: 422.8°Cat760mmHg
• Flash Point: 165.9°C
• Density: 1.203g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of diethyl [2-(2-nitrophenyl)ethyl]propanedioate

There total 2 articles about diethyl [2-(2-nitrophenyl)ethyl]propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-nitrostyrene (579-71-5) + diethyl malonate (105-53-3) → diethyl 2-[(2-nitrophenyl)ethyl]malonate (5345-19-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; Reflux;

DOI:10.1016/j.tetlet.2016.06.033

Reference yield:

→ diethyl 2-[(2-nitrophenyl)ethyl]malonate (5345-19-7)

Guidance literature:

/BRN= 3404217/;

DOI:10.1021/ja01652a090

Reference yield: 95.0%

diethyl 2-[(2-nitrophenyl)ethyl]malonate (5345-19-7) → (±)-diethyl 2-[(2-aminophenyl)ethyl]malonate

Guidance literature:

With iron; acetic acid; for 0.5h; Reflux; Inert atmosphere;

DOI:10.1080/00304948.2015.1066643

upstream raw materials:

2-nitrostyrene

diethyl malonate

Downstream raw materials:

bis-(2-nitro-phenethyl)-malonic acid diethyl ester