(R)-2-Phenoxypropan-1-OL

Base Information

• Chemical Name: (R)-2-Phenoxypropan-1-OL
• CAS No.: 64658-22-6
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• UNII: TW5PP4SJM9
• Nikkaji Number: J1.642.346G
• Mol file: 64658-22-6.mol

Synonyms:(R)-2-PHENOXYPROPAN-1-OL;TW5PP4SJM9;64658-22-6;2-Phenoxypropanol, (R)-;2-Phenoxypropanol, (-)-;(2R)-2-Phenoxy-1-propanol;2-Phenoxypropyl alcohol, (2R)-;UNII-TW5PP4SJM9;SCHEMBL7566883

Chemical Property of (R)-2-Phenoxypropan-1-OL

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 97.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CO)OC1=CC=CC=C1
• Isomeric SMILES: C[C@H](CO)OC1=CC=CC=C1

Technology Process of (R)-2-Phenoxypropan-1-OL

There total 28 articles about (R)-2-Phenoxypropan-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-2-phenoxypropionic acid ethyl ester (76671-56-2) → (R)-2-phenoxypropan-1-ol (64658-22-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Ambient temperature;

DOI:10.1002/hlca.19940770210

Reference yield: 97.0%

(R)-(2-benzyloxy-1-methyl)ethyl phenyl ether (221310-61-8) → (R)-2-phenoxypropan-1-ol (64658-22-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1h;

DOI:10.1016/S0040-4020(98)01128-4

Reference yield: 89.0%

(R)-di(naphthalen-1-yl)methyl-2-phenoxypropanoate (1345458-52-7) → (R)-2-phenoxypropan-1-ol (64658-22-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 1h; enantioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.0c00748

upstream raw materials:

(R)-2-phenoxypropionic acid ethyl ester

(S)-(-)-(2-benzyloxy-1-methyl)ethyl 4-methyl-benzenesulfonate

(R)-(2-benzyloxy-1-methyl)ethyl phenyl ether

(S)-(+)-(2-benzyloxy-1-methyl)ethyl 4-nitrobenzenesulfonate

Downstream raw materials:

(R)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

(R)-2-phenoxypropyl toluene-4-sulfonate

(R)-2-phenoxypropyl methanesulfonate

trimethyl-[3-(2-phenoxy-propyl)-cyclopenta-2,4-dienyl]-silane