1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-hydroxy-, ethyl ester

Base Information

Chemical Name:1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-hydroxy-, ethyl ester
CAS No.:64919-93-3
Molecular Formula:C12H11ClN2O3
Molecular Weight:266.684
Hs Code.:
DSSTox Substance ID:DTXSID201185617

Synonyms:64919-93-3;1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-hydroxy-, ethyl ester;SCHEMBL537642;SCHEMBL11426196;DTXSID201185617;Ethyl 1-(4-chlorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate

Suppliers and Price of 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-hydroxy-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-hydroxy-, ethyl ester

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:266.0458199
Heavy Atom Count:18
Complexity:376

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CC(=O)N(N1)C2=CC=C(C=C2)Cl

Technology Process of 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-hydroxy-, ethyl ester

There total 4 articles about 1H-Pyrazole-3-carboxylic acid, 1-(4-chlorophenyl)-5-hydroxy-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 40876-98-0,88330-76-1,125898-38-6
sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate

: 64919-93-3
ethyl 1-p-chlorophenyl-5-hydroxy-1H-pyrazole-3-carboxylate

Guidance literature:: With acetic acid; In water; benzene; for 3h; Heating;
DOI:10.1248/cpb.31.1228

Reference yield: 76.5%

: 87499-21-6
diethyl oxalacetate p-chlorophenylhydrazone

: 64919-93-3
ethyl 1-p-chlorophenyl-5-hydroxy-1H-pyrazole-3-carboxylate

Guidance literature:: With acetic acid; for 1h; Heating;
DOI:10.1248/cpb.31.1228

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 64919-93-3
ethyl 1-p-chlorophenyl-5-hydroxy-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 63.5 percent / H₂O / 2 h / Ambient temperature

2: 76.5 percent / acetic acid / 1 h / Heating

With acetic acid; In water;
DOI:10.1248/cpb.31.1228