10-Aminocamptothecin

Base Information

Chemical Name:10-Aminocamptothecin
CAS No.:86639-63-6
Molecular Formula:C20H17 N3 O4
Molecular Weight:363.373
Hs Code.:
DSSTox Substance ID:DTXSID301315223
Nikkaji Number:J430.444F
Pharos Ligand ID:3BX1T81MRCAL
ChEMBL ID:CHEMBL102252
Mol file:86639-63-6.mol

Synonyms:10-amino-20(S)-camptothecin;10-amino-CPT;10-aminocamptothecin;10-aminocamptothecin, (R)-isomer;10-aminocamptothecin, (S)-isomer

Suppliers and Price of 10-Aminocamptothecin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
10-AMINOCAMPTOTHECIN 95.00%
5MG
$ 499.44

Total 13 raw suppliers

Chemical Property of 10-Aminocamptothecin

Chemical Property:

Boiling Point:825.9oC at 760 mmHg
Flash Point:453.3oC
PSA：107.44000
Density:1.55g/cm3
LogP:2.24300
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:363.12190603
Heavy Atom Count:27
Complexity:775

Purity/Quality:

95%-98% ^*data from raw suppliers

10-AMINOCAMPTOTHECIN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)N)O
Isomeric SMILES:CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)N)O
Uses 10-Aminocamptothecin is a derivative of Camptothecin (C175150), an antitumor compound used in the treatment of hyperproliferative diseases.

Technology Process of 10-Aminocamptothecin

There total 16 articles about 10-Aminocamptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

: 86639-62-5
10-nitro-(20S)-camptothecin

: 86639-63-6
10-amino-20(S)-camptothecin

Guidance literature:: With hydrogen; platinum(IV) oxide; In 1,4-dioxane; ethanol; for 2h; under 760 Torr;
DOI:10.1248/cpb.39.3183

Reference yield: 87.0%

: 202745-28-6
((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl)-carbamic acid tert-butyl ester

: 86639-63-6
10-amino-20(S)-camptothecin

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/(SICI)1521-3765(199801)4:1<67::AID-CHEM67>3.0.CO;2-F

Reference yield:

: 86639-48-7
Camptothecin 1-oxide

: 86639-63-6
10-amino-20(S)-camptothecin

Guidance literature:: Multi-step reaction with 7 steps

1: 11.5 percent / 1 N aq. H₂SO₄ / dioxane / 0.5 h / Irradiation

2: H₂, acetic acid / PtO₂ / dioxane / 760 Torr

3: 98 percent / pyridine / 1 h / 70 °C

4: 96.3 percent / H₂SO₄, conc. aq. HNO₃ / 1 h

5: 82.3 percent / 20percent aq. H₂SO₄ / 2 h / Heating

6: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / dioxane / 2 h / Heating

7: 96.2 percent / H₂ / PtO₂ / ethanol; dioxane / 2 h / 760 Torr

With pyridine; sulfuric acid; hydrogen; nitric acid; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; platinum(IV) oxide; In 1,4-dioxane; ethanol;
DOI:10.1248/cpb.39.3183