METHYL PROPARGYL ETHER

Base Information

• Chemical Name: METHYL PROPARGYL ETHER
• CAS No.: 627-41-8
• Molecular Formula: C4H6 O
• Molecular Weight: 70.091
• Hs Code.: 2909199090
• European Community (EC) Number: 210-998-1
• DSSTox Substance ID: DTXSID70211762
• Nikkaji Number: J515K
• Wikidata: Q83086742
• ChEMBL ID: CHEMBL162694
• Mol file: 627-41-8.mol

Synonyms:Ether, methyl2-propynyl (6CI,7CI,8CI); (Methoxymethyl)acetylene; (Methoxymethyl)ethyne;1-Methoxy-2-propyne; 3-Methoxy-1-propyne; 3-Methoxypropyne; Methyl 2-propynylether; Methyl propargyl ether; Prop-2-yn-1-yl methyl ether; Propargyl methylether

Chemical Property of METHYL PROPARGYL ETHER

Chemical Property:

• Vapor Pressure: 187mmHg at 25°C
• Melting Point: 228 °C (decomp)
• Refractive Index: n20/D 1.396(lit.)
• Boiling Point: 61-62 °C(lit.)
• Flash Point: −1 °F
• PSA: 9.23000
• Density: 0.83 g/mL at 25 °C(lit.)
• LogP: 0.26600
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 70.041864811
• Heavy Atom Count: 5
• Complexity: 47.9

Purity/Quality:

98%, ^*data from raw suppliers

Methyl propargyl ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi
• Hazard Codes: F,Xi
• Statements: 11-36/37/38
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Ethers, Other
• Canonical SMILES: COCC#C

Technology Process of METHYL PROPARGYL ETHER

There total 17 articles about METHYL PROPARGYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

propargyl alcohol (107-19-7) + dimethyl sulfate (77-78-1) → propargyl alcohol methyl ether (627-41-8)

Guidance literature:

propargyl alcohol; With sodium hydroxide; In water;

dimethyl sulfate; In water; at 50 - 60 ℃;

DOI:10.1021/jo101355h

Reference yield: 71.0%

3,3-dimethoxyprop-1-yne (22537-06-0) → propargyl alcohol methyl ether (627-41-8)

Guidance literature:

With benzo[1,3,2]dioxaborole; In benzene; Ambient temperature;

DOI:10.1080/00397919108019775

Reference yield:

methanol (67-56-1) + propargyl bromide (106-96-7) → propargyl alcohol methyl ether (627-41-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jm0005555

upstream raw materials:

methanol

1,2,3-tribromopropane

1,2-dibromo-3-methoxypropane

1-bromo-3-methoxy-propene

Downstream raw materials:

3-Prop-2-ynyloxy-propionic acid ethyl ester

2-Methoxy-pent-4-ynoic acid ethyl ester

1-(Phenyl-ethyl-amino)-4-methoxy-butin-⁽²⁾

methyl 4-methoxy-trans-crotonate

Refernces

• 1、 Gillespie,Price. "-". . p. 780,781. Retrieved 1957.
• 2、 -. "PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF". Paragraph 0363-0365. . Retrieved 2021/02/26.
• 3、 Singh, Gurjaspreet,Mangat, Satinderpal Singh,Singh, Jandeep,Arora, Aanchal,Sharma, Ramesh K.. "Synthesis of polyfunctional triethoxysilanes by 'click silylation'". supporting information. p. 903 - 909. Retrieved 2015/03/03.