hydroxy(4-methylphenyl)methanesulfonic acid

Base Information

• Chemical Name: hydroxy(4-methylphenyl)methanesulfonic acid
• CAS No.: 41468-10-4
• Molecular Formula: C8H10 O4 S . Na
• Molecular Weight: 224.213
• Mol file: 41468-10-4.mol

Synonyms:Benzenemethanesulfonicacid, a-hydroxy-4-methyl-, monosodiumsalt (9CI); Methanesulfonic acid, hydroxy-p-tolyl-, sodium salt (6CI); NSC143372; Sodium a-hydroxy-4-methylbenzenemethanesulfonate

Chemical Property of hydroxy(4-methylphenyl)methanesulfonic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.456g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hydroxy(4-methylphenyl)methanesulfonic acid

There total 1 articles about hydroxy(4-methylphenyl)methanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-methyl-benzaldehyde (104-87-0) → α-hydroxy-α-toluenesulfonate (41468-10-4)

Guidance literature:

With sodium hydrogensulfite; In water; at 20 ℃; for 2h;

DOI:10.2174/1570178614666170203095116

Reference yield: 99.6%

α-hydroxy-α-toluenesulfonate (41468-10-4) + 1,2-diamino-benzene (95-54-5) → 2-(p-tolyl)-1H-benzimidazole (120-03-6)

Guidance literature:

In ethanol; for 3h; Heating;

Reference yield: 95.0%

α-hydroxy-α-toluenesulfonate (41468-10-4) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → trimethyl(4-methylbenzyloxy)silane (89200-92-0)

Guidance literature:

With sodium tetrahydroborate; montmorillonite K-10; In acetonitrile; at 20 ℃; for 0.2h;

DOI:10.1080/104265090969009

upstream raw materials:

4-methyl-benzaldehyde

Downstream raw materials:

2-(p-tolyl)-1H-benzimidazole

sodium α-anilino-α-toluenesulfonate

trans-p-methylcinnamic acid

trimethyl(4-methylbenzyloxy)silane

Refernces

• 1、 Vinay Kumar,Jaganmohan,Sandeep Reddy,Mohanty, Sandeep,Kumar, Jaydeep,Rao, Venkateswara. "Facile utilisation of aldehyde bisulfite adducts: Synthesis of (E)-1,2- diphenylethenes". . p. 109 - 114. Retrieved 2017/04/03.
• 2、 Yoon,Osman,Choon. "Potent sirtuin inhibition with 1,2,5-trisubstituted benzimidazoles". . p. 2094 - 2099. Retrieved 2016/11/18.