methyl 3-formyl-1-methyl-1H-indole-4-carboxylate

Base Information

Chemical Name:methyl 3-formyl-1-methyl-1H-indole-4-carboxylate
CAS No.:65923-20-8
Molecular Formula:C12H11NO3
Molecular Weight:217.224
Hs Code.:
DSSTox Substance ID:DTXSID10496233
Wikidata:Q82344953
Mol file:65923-20-8.mol

Synonyms:65923-20-8;methyl 3-formyl-1-methyl-1H-indole-4-carboxylate;methyl 3-formyl-1-methylindole-4-carboxylate;3-FORMYL-1-METHYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER;SCHEMBL702371;DTXSID10496233;MFCD09864027;AKOS005208576;VS-10612;CS-0314635;methyl3-formyl-1-methyl-1H-indole-4-carboxylate;F2113-0523

Suppliers and Price of methyl 3-formyl-1-methyl-1H-indole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Formyl-1-methyl-1H-indole-4-carboxylicAcidmethylester
100mg
$ 265.00

American Custom Chemicals Corporation
3-FORMYL-1-METHYL-1H-INDOLE-4-CARBOXYLIC ACID METHYL ESTER 95.00%
5MG
$ 498.92

Total 5 raw suppliers

Chemical Property of methyl 3-formyl-1-methyl-1H-indole-4-carboxylate

Chemical Property:

Melting Point:130 °C
Boiling Point:388.5±22.0 °C(Predicted)
PSA：48.30000
Density:1.21±0.1 g/cm3(Predicted)
LogP:1.77740
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:217.07389321
Heavy Atom Count:16
Complexity:292

Purity/Quality:

99% ^*data from raw suppliers

3-Formyl-1-methyl-1H-indole-4-carboxylicAcidmethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=C(C2=C(C=CC=C21)C(=O)OC)C=O

Technology Process of methyl 3-formyl-1-methyl-1H-indole-4-carboxylate

There total 4 articles about methyl 3-formyl-1-methyl-1H-indole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1444-12-8
1-methyl-1H-indole-4-carboxylic acid methyl ester

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 65923-20-8
3-formyl-1-methyl-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.5h;

1-methyl-1H-indole-4-carboxylic acid methyl ester; for 6h;

Reference yield:

: 53462-88-7
3-Formylindole-4-carboxylic acid methyl ester

: 74-88-4
methyl iodide

: 65923-20-8
3-formyl-1-methyl-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2006.12.054

Reference yield:

: 39830-66-5
methyl 1H-indole-4-carboxylate

: 65923-20-8
3-formyl-1-methyl-1H-indole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

1.2: 2 h / 20 °C

2.1: trichlorophosphate / 0.5 h / 0 °C

2.2: 6 h

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;