Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-

Base Information

Chemical Name:Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-
CAS No.:136816-76-7
Molecular Formula:C21H25N5O
Molecular Weight:363.4561
Hs Code.:
DSSTox Substance ID:DTXSID00159941
Nikkaji Number:J942.932H
Wikidata:Q83028313
ChEMBL ID:CHEMBL289969
Mol file:136816-76-7.mol

Synonyms:1-(3-(1-isopropylamino)-2-pyridinyl)-4-((1-H-indol-2-yl)carbonyl)piperazine;U 88204;U-88204;U-88204E

Suppliers and Price of Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-

Chemical Property:

Vapor Pressure:1.51E-15mmHg at 25°C
Boiling Point:625.2°Cat760mmHg
Flash Point:331.9°C
Density:1.26g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:363.20591044
Heavy Atom Count:27
Complexity:505

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=CC=CC=C4N3

Technology Process of Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)-

There total 4 articles about Piperazine, 1-(1H-indol-2-ylcarbonyl)-4-(3-((1-methylethyl)amino)-2-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 153473-24-6
1-tert-butoxycarbonyl-4-(3-nitro-2-pyridyl)piperazine

: 136816-76-7
1-(indolyl-2-carbonyl)-4-<3-<(1-methylethyl)amino>pyridyl>-piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) acetic acid, 2.) NaCNBH₃ / 1.) methanol, 0 deg C, 15 min, 2.) methanol, 0 deg C - RT

2: 83 percent / trifluoroacetic acid / CH₂Cl₂

3: 1.) 1.1'-carbonyldiimidazole / 1.) THF, 1 h, 2.) THF, RT, 18 h

With sodium cyanoborohydride; acetic acid; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 136818-14-9
1-[1,1-Dimethylethoxycarbonyl]-4-[3-(1-methylethylamino)-2-pyridinyl]piperazine

: 136816-76-7
1-(indolyl-2-carbonyl)-4-<3-<(1-methylethyl)amino>pyridyl>-piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / trifluoroacetic acid / CH₂Cl₂

2: 1.) 1.1'-carbonyldiimidazole / 1.) THF, 1 h, 2.) THF, RT, 18 h

With 1,1'-carbonyldiimidazole; trifluoroacetic acid; In dichloromethane;