N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE

Base Information

• Chemical Name: N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE
• CAS No.: 59907-22-1
• Molecular Formula: C9H10N2O3
• Molecular Weight: 194.19
• Hs Code.: 2924299090
• Mol file: 59907-22-1.mol

Synonyms:o-Acetotoluide,6-nitro- (4CI);o-Acetotoluidide, 6'-nitro- (7CI);2-Methyl-6-nitroacetanilide;2'-Methyl-6'-nitroacetanilide;3-Nitro-2-acetamidotoluene;NSC 243773;

Chemical Property of N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE

Chemical Property:

• Vapor Pressure: 7.87E-06mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 375.3 °C at 760 mmHg
• Flash Point: 180.8 °C
• PSA: 74.92000
• Density: 1.289 g/cm³
• LogP: 2.45780

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Methyl-6-nitro-phenyl)-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE

There total 18 articles about N-(2-METHYL-6-NITRO-PHENYL)-ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

acetamide (60-35-5) + 2-bromo-3-nitrotoluene (41085-43-2) → N-(2-methyl-6-nitrophenyl)acetamide (59907-22-1)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 16h;

DOI:10.1021/ol005654r

Reference yield: 90.2%

2-Methyl-6-nitroaniline (570-24-1) + acetic anhydride (108-24-7) → N-(2-methyl-6-nitrophenyl)acetamide (59907-22-1)

Guidance literature:

In chloroform; for 12h; Time; Reflux;

Reference yield: 85.0%

N,N-diacetyl-6-nitro-o-toluidine (82344-53-4) → N-(2-methyl-6-nitrophenyl)acetamide (59907-22-1)

Guidance literature:

With hydrogenchloride; In acetic acid; for 1.5h; Ambient temperature;

upstream raw materials:

2-Methyl-6-nitroaniline

acetic anhydride

N-(2-methylphenyl)acetamide

N,N-diacetyl-6-nitro-o-toluidine

Downstream raw materials:

2-Methyl-6-nitroaniline

2-methyl-4-nitroacetanilide

2,2'-diamino-6,6'-dimethylbiphenyl

2-chloro-6-methylaniline

Refernces

• 1、 Otevrel, Jan,Bobal, Pavel. "Biphenyl-Based Bis(thiourea) Organocatalyst for Asymmetric and syn -Selective Henry Reaction". supporting information. p. 593 - 603. Retrieved 2017/01/25.
• 2、 Kitamura, Mitsuru,Fukuma, Hiroaki,Kobayashi, Mitsuaki,Okayama, Shinya,Okauchi, Tatsuo. "Axially Chiral Bifunctional 8,8′-Biquinolyl: Synthesis of 7,7′-Dihydroxymethyl-8,8′-biquinolyl via Pd-Catalyzed Double C-H Oxidation of 7,7′-Dimethyl-8,8′-biquinolyl". . p. 3956 - 3960. Retrieved 2016/05/24.