Technology Process of Protostephanone
There total 20 articles about Protostephanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogen carbonate / CHCl3; diethyl ether; H2O / 0.25 h
2: 81 percent / phosphorus oxychloride / CHCl3 / 0.42 h / Heating
3: 84 percent / 3 h / Heating; in the dark
4: zinc dust, conc. hydrochloric acid / H2O
5: 1.) 1 M sulphuric acid, sodium nitrite, 2.) copper powder / 1.) -3 deg C, 30 min, 2.) acetone, -3 deg C, 2 h
With
hydrogenchloride; sulfuric acid; copper; sodium hydrogencarbonate; zinc; sodium nitrite; trichlorophosphate;
In
diethyl ether; chloroform; water;
DOI:10.1039/P19810002002
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl chloride, dimethylformamide / benzene / 20 °C
2: sodium hydrogen carbonate / CHCl3; diethyl ether; H2O / 0.25 h
3: 81 percent / phosphorus oxychloride / CHCl3 / 0.42 h / Heating
4: 84 percent / 3 h / Heating; in the dark
5: zinc dust, conc. hydrochloric acid / H2O
6: 1.) 1 M sulphuric acid, sodium nitrite, 2.) copper powder / 1.) -3 deg C, 30 min, 2.) acetone, -3 deg C, 2 h
With
hydrogenchloride; oxalyl dichloride; sulfuric acid; copper; sodium hydrogencarbonate; N,N-dimethyl-formamide; zinc; sodium nitrite; trichlorophosphate;
In
diethyl ether; chloroform; water; benzene;
DOI:10.1039/P19810002002
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogen carbonate / CHCl3; diethyl ether; H2O / 0.25 h
2: 81 percent / phosphorus oxychloride / CHCl3 / 0.42 h / Heating
3: 84 percent / 3 h / Heating; in the dark
4: zinc dust, conc. hydrochloric acid / H2O
5: 1.) 1 M sulphuric acid, sodium nitrite, 2.) copper powder / 1.) -3 deg C, 30 min, 2.) acetone, -3 deg C, 2 h
With
hydrogenchloride; sulfuric acid; copper; sodium hydrogencarbonate; zinc; sodium nitrite; trichlorophosphate;
In
diethyl ether; chloroform; water;
DOI:10.1039/P19810002002
