3-Acetyl-9-methylcarbazole

Base Information

• Chemical Name: 3-Acetyl-9-methylcarbazole
• CAS No.: 1484-05-5
• Molecular Formula: C15H13 N O
• Molecular Weight: 223.274
• Hs Code.: 2933990090
• NSC Number: 121198
• DSSTox Substance ID: DTXSID80298160
• Nikkaji Number: J45.429J
• Wikidata: Q63399330
• Mol file: 1484-05-5.mol

Synonyms:1484-05-5;3-Acetyl-9-methylcarbazole;1-(9-Methyl-9H-carbazol-3-yl)ethanone;1-(9-Methyl-9H-carbazol-3-yl)-ethanone;1-(9-methylcarbazol-3-yl)ethanone;NSC121198;CBMicro_003619;EC-000.1503;Cambridge id 5100177;SCHEMBL2026269;3-Acetyl-9-methyl-9H-carbazole;DTXSID80298160;SMSF0003185;6,8-Dichlorochromone-2-carboxylicacid;CB05379;NSC 121198;NSC-121198;BIM-0003522.P001;1-(9-methyl-9 h-carbazol-3-yl)-ethanone;1-(9-Methyl-9H-carbazol-3-yl)ethanone #;ethanone, 1-(9-methyl-9H-carbazol-3-yl)-;FT-0633594;A911335;Q63399330

Chemical Property of 3-Acetyl-9-methylcarbazole

Chemical Property:

• Vapor Pressure: 9.54E-05mmHg at 25°C
• Boiling Point: 338.9°Cat760mmHg
• Flash Point: 158.7°C
• PSA: 22.00000
• Density: 1.14g/cm³
• LogP: 3.53410
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 223.099714038
• Heavy Atom Count: 17
• Complexity: 314

Purity/Quality:

98.5% ^*data from raw suppliers

1-(9-Methyl-9H-carbazol-3-yl)ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC2=C(C=C1)N(C3=CC=CC=C32)C

Technology Process of 3-Acetyl-9-methylcarbazole

There total 8 articles about 3-Acetyl-9-methylcarbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.3%

N-methylcarbazole (1484-12-4) + acetic anhydride (108-24-7) → 1-(9-methyl-9H-carbazol-3-yl)ethanone (1484-05-5)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/d0nj02307h

Reference yield: 64.0%

N-methylcarbazole (1484-12-4) + acetyl chloride (75-36-5) → 1-(9-methyl-9H-carbazol-3-yl)ethanone (1484-05-5)

Guidance literature:

With aluminum (III) chloride; In chloroform; at 20 ℃; for 0.75h;

DOI:10.1021/jm300125e

Reference yield:

N-methylcarbazole (1484-12-4) + acetyl chloride (75-36-5) → 1-(9-methyl-9H-carbazol-3-yl)ethanone (1484-05-5) + 1,1'-(9-methyl-9H-carbazole-3,6-diyl)diethanone (1483-98-3)

Guidance literature:

With carbon disulfide; aluminium trichloride;

upstream raw materials:

N-methylcarbazole

acetyl chloride

3-acetylcarbazole

dimethyl sulfate

Downstream raw materials:

4-methyl-N′-(1-(9-methyl-9H-carbazol-3-yl)ethylidene)benzenesulfonohydrazide

3-(1-(4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-yl)ethyl)-9-methyl-9H-carbazole

9-methyl-3-(1-(4-(2-nitrophenyl)-1H-1,2,3-triazol-1-yl)ethyl)-9Hcarbazole

3-(1-(4-(benzyloxymethyl)-1H-1,2,3-triazol-1-yl)ethyl)-9-methyl-9H-carbazole

Refernces

• 1、 Tan, Jingyun,Wang, Chunfei,Zhang, Xuanjun. "Structure-reactivity relationship of probes based on the H2S-mediated reductive cleavage of the CC bond". . p. 11667 - 11677. Retrieved 2020/07/28.
• 2、 Bzeih, Tourin,Naret, Timothée,Hachem, Ali,Jaber, Nada,Khalaf, Ali,Bignon, Jerome,Brion, Jean-Daniel,Alami, Mouad,Hamze, Abdallah. "A general synthesis of arylindoles and (1-arylvinyl)carbazoles: Via a one-pot reaction from N -tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer". supporting information. p. 13027 - 13030. Retrieved 2016/11/09.