(3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

Base Information

Chemical Name:(3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride
CAS No.:666831-17-0
Molecular Formula:C₂₅H₃₄N₄O₃S
Molecular Weight:470.636
Hs Code.:

Synonyms:(3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

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Chemical Property of (3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

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Technology Process of (3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

There total 4 articles about (3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: (3R,4S)-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

: 635319-12-9
7-benzyloxymethyl-6-O-tert-butyl-9-deaza-9-formylhypoxanthine

: 666831-17-0
(3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1021/jm050269z

Reference yield:

: 666831-26-1
(3R,4S)-tert-butyl 3-hydroxy-4-((methylthio)methyl)pyrrolidine-1-carboxylate

: 666831-17-0
(3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 422 mg / aq. HCl / methanol

2: 78 percent / NaCNBH₃ / methanol / 20 °C

With hydrogenchloride; sodium cyanoborohydride; In methanol;
DOI:10.1021/jm050269z

Reference yield:

: 666831-24-9
tert-butyl (3R,4R)-3-hydroxy-4-[(methanesulfonyloxy)methyl]pyrrolidine-1-carboxylate

: 666831-17-0
(3R,4S)-1-[(7-benzyloxymethyl-6-tert-butoxy-9-deazapurin-9-yl)methyl]-3-hydroxy-4-methylthiomethylpyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 600 mg / dimethylformamide / 20 °C

2: 422 mg / aq. HCl / methanol

3: 78 percent / NaCNBH₃ / methanol / 20 °C

With hydrogenchloride; sodium cyanoborohydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm050269z