2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-(2-ethoxyphenyl)-1-piperazinyl]- 2-oxoethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-(2-ethoxyphenyl)-1-piperazinyl]- 2-oxoethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-
CAS No.:668980-40-3
Molecular Formula:C36H43ClN4O5
Molecular Weight:647.214
Hs Code.:

2(1H)-Isoquinolinecarboxylic acid,
3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-(2-ethoxyphenyl)-1-piperazinyl]-
2-oxoethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

Synonyms:

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-(2-ethoxyphenyl)-1-piperazinyl]- 2-oxoethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-(2-ethoxyphenyl)-1-piperazinyl]- 2-oxoethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3R)-

There total 4 articles about 2(1H)-Isoquinolinecarboxylic acid, 3-[[[(1R)-1-[(4-chlorophenyl)methyl]-2-[4-(2-ethoxyphenyl)-1-piperazinyl]- 2-oxoethyl]amino]carbonyl]-3,4-dihydro-, 1,1-dimethylethyl ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13339-01-0
1-(2-ethoxyphenyl)piperazine

: 252008-71-2
(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanine

: 668980-40-3
3-{1-(4-chloro-benzyl)-2-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0304109

Reference yield:

: 78879-20-6,144069-68-1,115962-35-1
D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid

: 668980-40-3
3-{1-(4-chloro-benzyl)-2-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 4-(dimethylamino)pyridine; 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 0 - 20 °C

2: aq. NaOH / methanol / 0 - 25 °C

3: 1-hydroxy-7-azabenzotriazole; diisopropylethylamine; O-(7-azobenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / CH₂Cl₂; dimethylformamide / 20 °C

With dmap; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0304109

Reference yield:

: 134166-72-6,24561-03-3
D-p-chlorophenylalanine methyl ester

: 668980-40-3
3-{1-(4-chloro-benzyl)-2-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-2-oxo-ethylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 4-(dimethylamino)pyridine; 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide*HCl / CH₂Cl₂ / 0 - 20 °C

2: aq. NaOH / methanol / 0 - 25 °C

3: 1-hydroxy-7-azabenzotriazole; diisopropylethylamine; O-(7-azobenzotriazol-1-yl)-1,1,3,3-tetramethyluronium PF₆ / CH₂Cl₂; dimethylformamide / 20 °C

With dmap; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0304109