12-Hydroxy-5,8,10 heptadecatrienoic acid

Base Information

Chemical Name:12-Hydroxy-5,8,10 heptadecatrienoic acid
CAS No.:50683-78-8
Molecular Formula:C₁₇H₂₈O₃
Molecular Weight:280.408
Hs Code.:
Mol file:50683-78-8.mol

Synonyms:12-Hht;Hydroxyheptadecatrienoic acid;12-hydroxy-5,8,10 heptadecatrienoic acid

Suppliers and Price of 12-Hydroxy-5,8,10 heptadecatrienoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 12-Hydroxy-5,8,10 heptadecatrienoic acid

Chemical Property:

Vapor Pressure:4.64E-10mmHg at 25°C
Boiling Point:451.8°C at 760 mmHg
Flash Point:241.1°C
PSA：57.53000
Density:0.992g/cm³
LogP:4.24120
XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:12
Exact Mass:280.20384475
Heavy Atom Count:20
Complexity:316

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC=CCC=CCCCC(=O)O)O
General Description 12-Hydroxy-5,8,10-heptadecatrienoic acid (12-HHT) is a metabolite of arachidonic acid that undergoes acid-catalyzed isomerization from its 5-cis form (5Z,8E,10E) to the 5-trans form (5E,8E,10E), characterized by a shift in UV absorption (λ_max = 232 nm) and thermodynamic properties (Δ_RG° = -1.42 kJ/mol, Δ_RH° = -3.50 kJ/mol). This exergonic and exothermic reaction is pH-dependent and follows first-order kinetics. The structural confirmation was achieved via GC-MS, identifying the trans-isomer as the equilibrium product.

Technology Process of 12-Hydroxy-5,8,10 heptadecatrienoic acid

There total 47 articles about 12-Hydroxy-5,8,10 heptadecatrienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 79171-56-5
(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid methyl ester

: 50683-78-8,54397-84-1,64234-42-0
12-HHT

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water;
DOI:10.1055/s-0033-1338961

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 542-78-9
Malondialdehyde

: 50683-78-8,54397-84-1,64234-42-0
(5Z,8Z,10Z)-12-Hydroxy-heptadeca-5,8,10-trienoic acid

Guidance literature:: With calcimycin; disodium hydrogenphosphate; potassium dihydrogenphosphate; platelet suspension of pig blood; In water; dimethyl sulfoxide; at 37 ℃; Kinetics; Mechanism; also with additives;
DOI:10.1002/(SICI)1521-4184(199811)331:11<359::AID-ARDP359>3.0.CO;2-B

Reference yield:

: 39647-93-3
(S)-(E)-(+)-1-Iodo-1-octen-3-ol

: C₂₀H₃₇BO₂

: 50683-78-8,54397-84-1,64234-42-0
12-HHT

Guidance literature:: (S)-(E)-(+)-1-Iodo-1-octen-3-ol; C₂₀H₃₇BO₂; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide; In tetrahydrofuran; water; at 40 ℃; Inert atmosphere;

In tetrahydrofuran; water; pH=5;
DOI:10.1039/c6ob02141g