Acetic acid, trichloro-, (1R,4S,5R)-4-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-ethenyl-2-methyl-5 -[(trichloroacetyl)amino]-2-cyclohexen-1-yl ester

Base Information

Chemical Name:Acetic acid, trichloro-, (1R,4S,5R)-4-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-ethenyl-2-methyl-5 -[(trichloroacetyl)amino]-2-cyclohexen-1-yl ester
CAS No.:674793-27-2
Molecular Formula:C18H21Cl6NO5
Molecular Weight:544.086
Hs Code.:

Acetic acid, trichloro-,
(1R,4S,5R)-4-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-ethenyl-2-methyl-5
-[(trichloroacetyl)amino]-2-cyclohexen-1-yl ester

Synonyms:

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Chemical Property of Acetic acid, trichloro-, (1R,4S,5R)-4-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-ethenyl-2-methyl-5 -[(trichloroacetyl)amino]-2-cyclohexen-1-yl ester

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Technology Process of Acetic acid, trichloro-, (1R,4S,5R)-4-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-ethenyl-2-methyl-5 -[(trichloroacetyl)amino]-2-cyclohexen-1-yl ester

There total 3 articles about Acetic acid, trichloro-, (1R,4S,5R)-4-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-5-ethenyl-2-methyl-5 -[(trichloroacetyl)amino]-2-cyclohexen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 253674-40-7
2,2,2-Trichloro-N-[(1R,2S,4S,5S)-4,5-dibromo-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-methyl-1-vinyl-cyclohexyl]-acetamide

: 674793-27-2
Trichloro-acetic acid (1R,4S,5R)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-5-vinyl-cyclohex-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / K₂CO₃ / methanol / 15 h / 20 °C

2: aq. AcOH / tetrahydrofuran / 18 h / 20 °C

3: pyridine / 0.17 h

With pyridine; potassium carbonate; acetic acid; In tetrahydrofuran; methanol;
DOI:10.1002/chem.200305111

Reference yield:

: 76-02-8
trifluoroacetyl chloride

: 674793-26-1
(1R,4S,5R)-5-Amino-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-5-vinyl-cyclohex-2-enol

: 674793-27-2
Trichloro-acetic acid (1R,4S,5R)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-5-vinyl-cyclohex-2-enyl ester

Guidance literature:: With pyridine; for 0.166667h;
DOI:10.1002/chem.200305111

Reference yield:

: 162089-64-7
(1S,6S,1'S)-trichloro-N-[1-vinyl-4-methyl-6-(3',3'-dimethyl-2',4'-dioxolanyl)-cyclohex-3-enyl]acetamide

: 674793-27-2
Trichloro-acetic acid (1R,4S,5R)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-5-(2,2,2-trichloro-acetylamino)-5-vinyl-cyclohex-2-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / PyHBr₃; K₂CO₃ / CH₂Cl₂

2: 78 percent / K₂CO₃ / methanol / 15 h / 20 °C

3: aq. AcOH / tetrahydrofuran / 18 h / 20 °C

4: pyridine / 0.17 h

With pyridine; potassium carbonate; acetic acid; pyridinium hydrobromide perbromide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/chem.200305111