253674-40-7Relevant academic research and scientific papers
Stereocontrolled synthesis of (-)-5,11-dideoxytetrodotoxin
Nishikawa, Toshio,Asai, Masanori,Ohyabu, Norio,Yamamoto, Noboru,Isobe, Minoru
, p. 3081 - 3084 (1999)
New derivatives of an intriguing marine natural product are now accessible. The first asymmetric synthesis of the simple tetrodotoxin analogue, 5,11-dideoxytetrodotoxin (3), was achieved. Hydroxylation at position C8 of the key intermediate 1 relied on th
Stereocontrolled Synthesis of 8,11-Dideoxytetrodotoxin, An Unnatural Analogue of Puffer Fish Toxin
Nishikawa, Toshio,Urabe, Daisuke,Yoshida, Kazumasa,Iwabuchi, Tomoko,Asai, Masanori,Isobe, Minoru
, p. 452 - 462 (2007/10/03)
8,11-Dideoxytetrodotoxin, an unnatural tetrodotoxin analogue, was synthesized in a highly stereoselective manner from a common intermediate from our synthetic studies on tetrodotoxin. The key features in the synthesis were as follows: neighboring group pa
Stereocontrolled synthesis of (-)-5,11-dideoxytetrodotoxin
Asai, Masanori,Nishikawa, Toshio,Ohyabu, Norio,Yamamoto, Noboru,Isobe, Minoru
, p. 4543 - 4558 (2007/10/03)
Asymmetric synthesis of (-)-5,11-dideoxytetrodotoxin, an analog of puffer fish toxin, was accomplished from a common key intermediate through a novel hydroxylation at the C-8 position with neighboring group participation of trichloroacetamide, a highly st
