2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline

Base Information

• Chemical Name: 2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline
• CAS No.: 7149-64-6
• Molecular Formula: C16H17N
• Molecular Weight: 223.318
• NSC Number: 72278
• DSSTox Substance ID: DTXSID20290986
• Nikkaji Number: J502.142A
• ChEMBL ID: CHEMBL278781

Synonyms:7149-64-6;2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline;CHEMBL278781;NSC 72278;NSC72278;NCIOpen2_003822;Oprea1_032773;Oprea1_574755;SCHEMBL8415128;DTXSID20290986;BDBM50017054;NSC-72278;1-Phenyl-1,2,3,4-tetrahydro-2-methylisoquinoline;1-phenyl-N-methyl-1,2,3,4-tetrahydro-isoquinoline;2-Methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinoline

Chemical Property of 2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline

Chemical Property:

• Vapor Pressure: 0.000302mmHg at 25°C
• Boiling Point: 321.2°Cat760mmHg
• Flash Point: 134.7°C
• Density: 1.055g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 223.136099547
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=CC=CC=C2C1C3=CC=CC=C3

Technology Process of 2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline

There total 26 articles about 2-methyl-1-phenyl-3,4-dihydro-1H-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile (63720-66-1) + phenylmagnesium bromide → 2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (7149-64-6)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 0.0333333h;

Reference yield: 90.0%

methanol (67-56-1) + 1-phenyl-3,4-dihydroisoquinoline (52250-50-7) → 2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (7149-64-6)

Guidance literature:

With C₂₅H₂₇ClIrN₄⁽¹⁺⁾*Cl^(1-); caesium carbonate; at 125 ℃; for 12h; Schlenk technique;

DOI:10.1016/j.jcat.2021.08.037

Reference yield: 90.0%

N-formyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline (80574-72-7) → 2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline (7149-64-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.3987/com-97-s70

upstream raw materials:

2-methyl-1-phenyl-1,2-dihydroisoquinoline

2-methyl-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile

N-methyl-1,2,3,4-tetrahydroisoquinoline N-oxide

dimethyl sulfate

Downstream raw materials:

2,2-dimethyl-1-phenyl-1,2,3,4-tetrahydro-isoquinolinium; iodide

2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline N-oxide

3-methyl-1-phenyl-1,3,4,5-tetrahydro-2,3-benzoxazepine

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