TRIMETHYL-BETA-CYCLODEXTRIN

Base Information

• Chemical Name: TRIMETHYL-BETA-CYCLODEXTRIN
• CAS No.: 55216-11-0
• Molecular Formula: C63H112 O35
• Molecular Weight: 1429.56
• Hs Code.: 29400090
• Mol file: 55216-11-0.mol

Synonyms:2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane,b-cyclodextrin deriv.;2,3,6-Tri-O-methyl-b-cyclodextrin; 2,3,6-Trimethyl-b-cyclodextrin; Cydex-b; Hepta-(2,3,6-tri-oxy-methyl)-b-cyclodextrin;Heptakis(2,3,6-tri-O-methyl)-b-cyclodextrin; Heptakis(2,3,6-trimethyl)-b-cyclodextrin; Hydrodex b-PM; Me21-b-CD; Permethyl-b-cyclodextrin; Permethylated b-cyclodextrin; TRIMEB; Tri-O-methyl-b-cyclodextrin; Trimethyl-b-cyclodextrin; b-Cyclodextrin permethyl ether

Chemical Property of TRIMETHYL-BETA-CYCLODEXTRIN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 170-178 °C(lit.)
• Refractive Index: 160 ° (C=1, CHCl3)
• Boiling Point: 1108.3°C at 760 mmHg
• Flash Point: 324.6°C
• PSA: 323.05000
• Density: 1.27g/cm³
• LogP: -1.49450
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL, slightly turbid, colorless

Purity/Quality:

98%,99%, ^*data from raw suppliers

Trimethyl-β-cyclodextrin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Trimethyl-β-cyclodextrin (CAS# 55216-11-0) is β-cyclodextrin (C987830) derivative used to solubilize steroids in aqueous solution to increase their bioavailability. Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin may be used:To investigate the crystal structure of its complexes with m-iodophenol, 4-biphenylacetic acid and (R)- and (S)-flurbiprofen by X-ray analysis.To study the candidature of its complex with vitamin A for potential application as a drug delivery system for ophthalmic applications by high sensitivity fluorescence spectrometry and high pressure liquid chromatography (HPLC) techniques.In the determination of the analyte composition in commercial samples by HPLC coupled to mass spectrometry (MS). Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin may be used:To investigate the crystal structure of its complexes with m-iodophenol, 4-biphenylacetic acid and (R)- and (S)-flurbiprofen by X-ray analysis.To study the candidature of its complex with vitamin A for potential application as a drug delivery system for ophthalmic applications by high sensitivity fluorescence spectrometry and high pressure liquid chromatography (HPLC).In the determination of analyte composition in commercial samples by HPLC coupled to mass spectrometry (MS).

Technology Process of TRIMETHYL-BETA-CYCLODEXTRIN

There total 10 articles about TRIMETHYL-BETA-CYCLODEXTRIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dimethyl sulfate (77-78-1) + β‐cyclodextrin (7585-39-9) → 2,3,6-trimethyl-beta-cyclodextrin (55216-11-0)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; for 48h;

DOI:10.3390/molecules26185669

Reference yield: 90.0%

β‐cyclodextrin (7585-39-9) + methyl iodide (74-88-4) → 2,3,6-trimethyl-beta-cyclodextrin (55216-11-0)

Guidance literature:

β‐cyclodextrin; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In dimethyl sulfoxide; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201200404

Reference yield: 43.0%

methanol (67-56-1) + 6A-O-(tert-Butyldimethylsilyl)heptakis(2,3-di-O-methyl)-6B,6C,6D,6E,6F,6G-hexa-O-methyl-β-cyclodextrin (150885-21-5) → 6-monohydroxy permethylated β-cyclodextrin (94789-61-4) + 2,3,6-trimethyl-beta-cyclodextrin (55216-11-0)

Guidance literature:

With ammonium fluoride; for 24h; Heating;

DOI:10.1016/0040-4039(96)01545-6

upstream raw materials:

β‐cyclodextrin

methyl iodide

dimethyl sulfate

methanol

Downstream raw materials:

C₁₂H₁₀N₂O*C₆₃H₁₁₂O₃₅

Refernces

• 1、 Klepel, Florian,Ravoo, Bart Jan. "Photo-responsive host-guest complexation directs dynamic covalent condensation of phenyl boronic acid andd-fructose". . p. 3207 - 3210. Retrieved 2021.
• 2、 Chen, Zhen,Bradshaw, Jerald S.,Lee, Milton L.. "A convenient synthesis of mono-6-hydroxy permethylated β-cyclodextrin via tert-butyldimethylsilylation". . p. 6831 - 6834. Retrieved 1996.
• 3、 Bucur, Stefan,Niculaua, Marius,Ciobanu, Catalina Ionica,Lungu, Neculai Catalin,Mangalagiu, Ionel. "A simple synthesis route for selectively methylated β-cyclodextrin using a copper complex sandwich protecting strategy". . . Retrieved 2021/09/28.