1,4-Dipiperidino-2-butyne

Base Information

• Chemical Name: 1,4-Dipiperidino-2-butyne
• CAS No.: 7498-32-0
• Molecular Formula: C₁₄H₂₄N₂
• Molecular Weight: 220.358
• NSC Number: 407430
• UNII: N86SF6ECY2
• DSSTox Substance ID: DTXSID60225939
• Nikkaji Number: J50.648F
• Wikidata: Q83105149
• ChEMBL ID: CHEMBL1883942
• Mol file: 7498-32-0.mol

Synonyms:1,4-Dipiperidino-2-butyne;Piperidine, 1,1'-(2-butyne-1,4-diyl)bis-;Piperidine, 1,1'-(2-butynylene)di-;1,1'-(2-Butynylene)dipiperidine;7498-32-0;N86SF6ECY2;MLS003171611;NSC-407430;NSC 407430;BRN 0149049;NSC407430;UNII-N86SF6ECY2;4-20-00-01207 (Beilstein Handbook Reference);CHEMBL1883942;DTXSID60225939;Piperidine,1'-(2-butynylene)di-;1,4-DIPIPERIDYL-2-BUTYNE;1,4-di(piperidin-1-yl)but-2-yne;WLN: T6NTJ A2UU2- AT6NTJ;SMR001875488;Piperidine,1'-(2-butyne-1,4-diyl)bis-;1,1'-(2-BUTYNE-1,4-DIYL)BIS(PIPERIDINE)

Chemical Property of 1,4-Dipiperidino-2-butyne

Chemical Property:

• Boiling Point: 322.7oC at 760 mmHg
• Flash Point: 138oC
• PSA: 6.48000
• Density: 0.979g/cm3
• LogP: 1.83740
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 220.193948774
• Heavy Atom Count: 16
• Complexity: 224

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCN(CC1)CC#CCN2CCCCC2

Technology Process of 1,4-Dipiperidino-2-butyne

There total 3 articles about 1,4-Dipiperidino-2-butyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

piperidine (110-89-4) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + calcium carbide (75-20-7) → 1,4-di(piperidin-1-yl)but-2-yne (7498-32-0)

Guidance literature:

With water; copper(l) chloride; In dimethyl sulfoxide; at 100 ℃; for 4h; Inert atmosphere;

DOI:10.3184/174751917X14949427622099

Reference yield:

piperidine (110-89-4) + 1,4-Dichloro-2-butyne (821-10-3) → 1,4-di(piperidin-1-yl)but-2-yne (7498-32-0)

Guidance literature:

Reference yield:

piperidine (110-89-4) + diiodo 1,4-butyne-2 (116529-73-8) → 1,4-di(piperidin-1-yl)but-2-yne (7498-32-0)

Guidance literature:

With benzene; anfangs bei -40grad;

upstream raw materials:

piperidine

diiodo 1,4-butyne-2

1,4-Dichloro-2-butyne

formaldehyd

Downstream raw materials:

(1,4-dipiperidino-2-butyne)bis(tri-o-tolylphosphite)nickel⁽⁰⁾

(1,4-dipiperidino-2-butyne)bis(trithymylphosphite)nickel⁽⁰⁾

Hexakis(N-piperidinomethyl)benzen

Refernces