54087-03-5

Basic information

• Product Name: 6-Chloropyridine-2-carbaldehyde
• Synonyms: 6-Chloropyridine-2-carbaldehyde;6-Chloropicolinaldehyde;6-chloro-2-pyridinecarbaldehyde;6--Chloro-2-pyridinecarboxaldehyde;6-chloropyridine-2-carboxaldehyde;2-Chloro-6-formylpyridine, 6-Chloropicolinaldehyde
• CAS NO: 54087-03-5
• Molecular Formula: C₆H₄ClNO
• Molecular Weight: 141.56
• Mol File: 54087-03-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 68-69°
• Boiling Point: 218.969 °C at 760 mmHg
• Flash Point: 86.229 °C
• Appearance: White/Powder
• Density: 1.332 g/cm³
• Vapor Pressure: 0.122mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 1.00±0.10(Predicted)
• CAS DataBase Reference: 6-Chloropyridine-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloropyridine-2-carbaldehyde(54087-03-5)
• EPA Substance Registry System: 6-Chloropyridine-2-carbaldehyde(54087-03-5)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• HazardClass: IRRITANT
• Hazardous Substances Data: 54087-03-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H4ClNO/c7-6-3-1-2-5(4-9)8-6/h1-4H

Upstream product

• 109-09-1 2-chloropyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 33252-29-8 6-chloro-pyridine-2-carbonitrile 
• 258506-66-0 2-chloro-5-iodo-pyridine 
• 18368-63-3 6-chloro-2-picoline 
• 4684-94-0 6-chloropicolinic acid 
• 86209-84-9 2-acetoxymethyl-6-chloropyridine 
• 52313-59-4 2-Chloro-6-methylpyridine N-oxide 
• 2591-86-8 N-Formylpiperidine 
• 33674-97-4 6-chloro-2-pyridinemethanol 

Downstream Products

• 1026587-36-9 2-chloro-6-(difluoromethyl)pyridine 
• 1352067-74-3 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(6-chloropyridin-2-yl)propyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid 
• 1421236-76-1 (R)-N-((1R,2R)-3-((S)-4-benzyl-5,5-dimethyl-2-oxooxazolidin-3-yl)-1-(6-chloropyridin-2-yl)-2-methyl-3-oxopropyl)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)

The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.

Method for preparing aldehyde and acid by electrochemical dehydrochlorination of polychloromethylpyridine derivatives

The invention discloses a method for preparing aldehyde and an acid by electrochemical dechlorination of a polychloromethylpyridine derivative, the method comprises the following steps: dissolving thepolychloromethylpyridine derivative in an acetic acid and acetate- containing buffer solution to obtain an electrolytic reaction solution; taking the electrolytic reaction solution as a cathode liquid, performing electrolytic reduction dechlorination reaction at a cathode, and hydrolyzing in the solution to obtain a polychlorinated pyridylaldehyde or acid derivative. The polychloromethylpyridinederivative is shown in formula (I), and the product polychlorinated pyridylaldehyde or acid derivative is shown in formula (II): in the formula (I), m is 0, 1, 2, 3 or 4, n is 0 or 1, and R' is an easy-to-oxidize or easy-to-hydrolyze substituent. The m and the R' in the formula (II) are same as that in the formula (I), R is H or OH, no waste acid is generated in the preparation process, the easy-to-oxidize or easy-to-hydrolyze substituent contained in the polychloromethylpyridine derivative and carbon-chlorine bonds on pyridine rings are not affected, and the recovery conversion rate is high.

TMSCH2Li-LiDMAE: a new nonnucleophilic reagent for C-2 lithiation of halopyridines

A new superbasic reagent has been discovered by combining TMSCH2Li and LiDMAE in hexane. This reagent was found highly efficient for the C-2 lithiation of sensitive chloro- and fluoropyridines. The metallation occurred chemo- and regioselectively at 0 °C avoiding the nucleophilic addition or substrate degradation commonly obtained with other alkyllithiums even at lower temperatures.