Benzaldehyde, 5-chloro-2-hydroxy-, [4-[3-methyl-3-(2,4,6-trimethylphenyl)cyclobutyl]-2-thiazolyl]hydrazone

Base Information

• Chemical Name: Benzaldehyde, 5-chloro-2-hydroxy-, [4-[3-methyl-3-(2,4,6-trimethylphenyl)cyclobutyl]-2-thiazolyl]hydrazone
• CAS No.: 676519-49-6
• Molecular Formula: C24H26ClN3OS
• Molecular Weight: 440.009
• Mol file: 676519-49-6.mol

Synonyms:

Chemical Property of Benzaldehyde, 5-chloro-2-hydroxy-, [4-[3-methyl-3-(2,4,6-trimethylphenyl)cyclobutyl]-2-thiazolyl]hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzaldehyde, 5-chloro-2-hydroxy-, [4-[3-methyl-3-(2,4,6-trimethylphenyl)cyclobutyl]-2-thiazolyl]hydrazone

There total 2 articles about Benzaldehyde, 5-chloro-2-hydroxy-, [4-[3-methyl-3-(2,4,6-trimethylphenyl)cyclobutyl]-2-thiazolyl]hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(2-hydroxy-5-chlorobenzylidene) thiosemicarbazide (20234-13-3) + 2-chloro-1-[3-methyl-3-(2,4,6-trimethylphenyl)cyclobutyl]-ethan-1-one (331415-58-8) → 2-(2-hydroxy-5-chloro)benzaldehyde-[4-(3-methyl-3-mesitylcyclobutyl)-1,3-thiazol-2-yl]hydrazone (676519-49-6)

Guidance literature:

In ethanol; at 50 ℃;

DOI:10.1002/hc.10201

Reference yield:

5-chlorosalicyclaldehyde (635-93-8) → 2-(2-hydroxy-5-chloro)benzaldehyde-[4-(3-methyl-3-mesitylcyclobutyl)-1,3-thiazol-2-yl]hydrazone (676519-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / ethanol / Heating

2: K₂CO₃ / ethanol / Heating

With potassium carbonate; toluene-4-sulfonic acid; In ethanol;

DOI:10.1016/j.ejmech.2005.01.013

Reference yield:

copper(II) acetate monohydrate (6046-93-1) + 2-(2-hydroxy-5-chloro)benzaldehyde-[4-(3-methyl-3-mesitylcyclobutyl)-1,3-thiazol-2-yl]hydrazone (676519-49-6) → Cu(C24H25N3OSCl)2 (676519-56-5)

Guidance literature:

In ethanol; soln. of Cu(CH3COO)2*H2O added dropwise to soln. of C24H26N3OSCl with continuous stirring; mixt. refluxed for 1 h and left to stand overnight atroom temp.; ppt.; filtered, washed with cold ethanol and water for several times; dried in vac. at 60°C (over P4O10); stored in dessicator over CaCl2;

DOI:10.1016/j.physb.2004.09.097

upstream raw materials:

1-(2-hydroxy-5-chlorobenzylidene) thiosemicarbazide

2-chloro-1-[3-methyl-3-(2,4,6-trimethylphenyl)cyclobutyl]-ethan-1-one

5-chlorosalicyclaldehyde

Downstream raw materials:

Ni(C₂₄H₂₅N₃OSCl)2

Zn(C₂₄H₂₅N₃OSCl)2

Cu(C₂₄H₂₅N₃OSCl)2

Co(C₂₄H₂₅N₃OSCl)2