(3R)-1,3-Diphenylbutane

Base Information

• Chemical Name: (3R)-1,3-Diphenylbutane
• CAS No.: 17293-55-9
• Molecular Formula: C₁₆H₁₈
• Molecular Weight: 210.319
• Mol file: 17293-55-9.mol

Synonyms:Benzene,1,1'-(1-methyl-1,3-propanediyl)bis-, (R)-; Butane, 1,3-diphenyl-, (-)- (8CI);(3R)-1,3-Diphenylbutane; (R)-(-)-1,3-Diphenylbutane

Chemical Property of (3R)-1,3-Diphenylbutane

Chemical Property:

• Boiling Point: 295.1°Cat760mmHg
• Flash Point: 134.3°C
• PSA: 0.00000
• Density: 0.97g/cm³
• LogP: 4.42290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-1,3-Diphenylbutane

There total 105 articles about (3R)-1,3-Diphenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(rac)-(3-iodobutyl)benzeze (59456-20-1) + phenylmagnesium chloride (100-59-4) → 1,3-diphenylbutane (1520-44-1,17293-53-7,17293-55-9)

Guidance literature:

With [Fe(bis(oxazolinylphenyl)amido-Ph)Cl₂]; In tetrahydrofuran; at -40 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0034-1380136

Reference yield: 93.0%

2-bromo-4-phenylbutane (143097-80-7,21953-83-3) + phenylmagnesium chloride (100-59-4) → 1,3-diphenylbutane (1520-44-1,17293-53-7,17293-55-9)

Guidance literature:

With [Fe(bis(oxazolinylphenyl)amido-Ph)Cl₂]; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/om501122p

Reference yield: 57.0%

phenylmagnesium bromide (100-58-3) + o-n-butyliodobenzene (110349-12-7) → 1-butylbenzene (104-51-8) + 1,3-diphenylbutane (1520-44-1,17293-53-7,17293-55-9)

Guidance literature:

With dichloro(N,N,N’,N‘-tetramethylethylenediamine)zinc; 1,3-bis(2,6-diisopropylphenyl)imidazolidinium chloride; iron(III) acetylacetonate; In fluorobenzene; at 50 ℃; for 2h; Reagent/catalyst; Solvent; regioselective reaction;

DOI:10.1021/acscatal.7b03458

upstream raw materials:

styrene

ethylbenzene

but-2-ene-1,3-diyldibenzene

phenethylmagnesium bromide

Downstream raw materials:

1,1-diphenylbutane

Refernces

• 1、 Liu, Chen-Fei,Luo, Xiaohua,Wang, Hongyu,Koh, Ming Joo. "Catalytic Regioselective Olefin Hydroarylation(alkenylation) by Sequential Carbonickelation-Hydride Transfer". supporting information. p. 9498 - 9506. Retrieved 2021/07/19.
• 2、 Ludwig, Jacob R.,Simmons, Eric M.,Wisniewski, Steven R.,Chirik, Paul J.. "Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross Coupling". . . Retrieved 2020/11/02.