Remifentanil

Base Information Edit

Chemical Name:Remifentanil
CAS No.:132875-61-7
Molecular Formula:C20H28 N2 O5
Molecular Weight:376.453
Hs Code.:2933399080
European Community (EC) Number:685-601-1
UNII:P10582JYYK
DSSTox Substance ID:DTXSID00157826
Nikkaji Number:J423.836B
Wikipedia:Remifentanil
Wikidata:Q417902
NCI Thesaurus Code:C66513
RXCUI:73032
Pharos Ligand ID:JPPW3VBLDR1S
Metabolomics Workbench ID:43170
ChEMBL ID:CHEMBL1005
Mol file:132875-61-7.mol

Synonyms:3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester;GI 87084B;GI-87084B;GI87084B;remifentanil;remifentanil hydrochloride;remifentanil monohydrochloride;Ultiva

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Remifentanil Edit

Chemical Property:

Boiling Point:487.8°Cat760mmHg
PKA:6.65±0.20(Predicted)
Flash Point:248.8°C
PSA：76.15000
Density:1.171g/cm³
LogP:1.93820
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:376.19982200
Heavy Atom Count:27
Complexity:523

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC
Recent ClinicalTrials:Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients
Recent EU Clinical Trials:Opioid-Free analgesia in Intensive Care Unit
Recent NIPH Clinical Trials:Examination of sedative and analgesic requirements in a robotic anesthesia system(Automated delivery of three intravenous anesthetics using robotic anesthesia system for TIVA)
Uses Analgesic.
Clinical Use Analgesic Induction of anaesthesia
Drug interactions Potentially hazardous interactions with other drugs Anti-arrhythmics: delayed absorption of mexiletine. Antidepressants: possible CNS excitation or depression (hypertension or hypotension) in patients also receiving MAOIs (including moclobemide) - avoid; possibly increased sedative effects with tricyclics. Antihistamines: sedative effects possibly increased with sedating antihistamines. Antipsychotics: enhanced sedative and hypotensive effect. Antivirals: concentration possibly increased by ritonavir (risk of toxicity) - avoid. Dopaminergics: avoid with selegiline. Nalmefene: avoid concomitant use. Sodium oxybate: enhanced effect of sodium oxybate - avoid.

Technology Process of Remifentanil

There total 11 articles about Remifentanil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%