Cyclohexanol, 5-methyl-2-(1-methylethyl)-, benzoate, (1R,2S,5R)-rel-

Base Information

• Chemical Name: Cyclohexanol, 5-methyl-2-(1-methylethyl)-, benzoate, (1R,2S,5R)-rel-
• CAS No.: 612-33-9
• Molecular Formula: C17H24O2
• Molecular Weight: 260.376
• Mol file: 612-33-9.mol

Synonyms:Cyclohexanol, 5-methyl-2-(1-methylethyl)-, benzoate, (1R,2S,5R)-rel-;(+-)-O-Benzoyl-menthol;D,L-menthyl benzoate;(+/-)-menthyl benzoate;menthol benzoate;Benzoic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester;dl-menthyl benzoate;

Chemical Property of Cyclohexanol, 5-methyl-2-(1-methylethyl)-, benzoate, (1R,2S,5R)-rel-

Chemical Property:

• Boiling Point: 341.1°Cat760mmHg
• Flash Point: 154.9°C
• PSA: 26.30000
• Density: 1.01g/cm³
• LogP: 4.30420

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanol, 5-methyl-2-(1-methylethyl)-, benzoate, (1R,2S,5R)-rel-

There total 43 articles about Cyclohexanol, 5-methyl-2-(1-methylethyl)-, benzoate, (1R,2S,5R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(-)-menthol (2216-51-5) + benzoic acid anhydride (93-97-0) → L-menthyl benzoate (612-33-9,31481-49-9,38649-18-2,50465-37-7,58641-29-5,71617-14-6,87038-98-0,88764-74-3,88764-75-4,91840-42-5,6284-35-1)

Guidance literature:

With 1-[bis(trifluoromethanesulfonyl)methyl]-2,3,4,5,6-pentafluorobenzene;

DOI:10.1002/1521-3773(20011105)40:21<4077::AID-ANIE4077>3.0.CO;2-1

Reference yield: 97.0%

(-)-menthol (2216-51-5) + N-methyl-N-phenyl-benzamide (1934-92-5) → L-menthyl benzoate (612-33-9,31481-49-9,38649-18-2,50465-37-7,58641-29-5,71617-14-6,87038-98-0,88764-74-3,88764-75-4,91840-42-5,6284-35-1)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 1,3-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene; In toluene; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01758

Reference yield: 95.0%

(-)-menthol (2216-51-5) + benzoyl chloride (98-88-4) → L-menthyl benzoate (612-33-9,31481-49-9,38649-18-2,50465-37-7,58641-29-5,71617-14-6,87038-98-0,88764-74-3,88764-75-4,91840-42-5,6284-35-1)

Guidance literature:

(-)-menthol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃;

benzoyl chloride; In tetrahydrofuran; hexane; dichloromethane; for 2h;

DOI:10.1080/00397919708005004

upstream raw materials:

(-)-menthol

2,2,2-trichloroacetophenone

benzoyl chloride

benzoic acid anhydride

Downstream raw materials:

(S)-2-p-tolylsulfinylmethylphenyl ketone

(R)-p-tolylsulfinylacetophenone

(-)-menthol

benzoic acid methyl ester