Technology Process of Facinicline hydrochloride
There total 5 articles about Facinicline hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride; 1H-Indazole-3-carboxylic acid;
With
thionyl chloride;
N,N-dimethyl-formamide;
In
toluene;
at 80 ℃;
for 4h;
With
triethylamine;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 4h;
With
hydrogenchloride;
In
methanol; tert-butyl methyl ether; water;
at 5 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: water / 3 h / 25 - 30 °C
2.1: dichloromethane / 2 h / 40 °C
3.1: aluminum (III) chloride / dichloromethane / 2 h / 30 °C / Reflux
4.1: hydrogenchloride; acetic acid / water / 1 h / 90 °C
4.2: 0.5 h / 115 °C
5.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 4 h / 80 °C
5.2: 4 h / 70 °C
5.3: 5 °C
With
hydrogenchloride; aluminum (III) chloride; thionyl chloride; acetic acid;
N,N-dimethyl-formamide;
In
dichloromethane; water; toluene;
