Facinicline hydrochloride

Base Information

Chemical Name:Facinicline hydrochloride
CAS No.:677305-02-1
Molecular Formula:C15H18N4O.ClH
Molecular Weight:
Hs Code.:
UNII:O6J463N18M
Wikidata:Q27285409
ChEMBL ID:CHEMBL5095032

Synonyms:N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride;RG3487

Suppliers and Price of Facinicline hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Facinicline hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:306.1247389
Heavy Atom Count:21
Complexity:380

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN2CCC1C(C2)NC(=O)C3=NNC4=CC=CC=C43.Cl
Isomeric SMILES:C1CN2CCC1[C@@H](C2)NC(=O)C3=NNC4=CC=CC=C43.Cl
Recent ClinicalTrials:Study to Evaluate the Safety and Efficacy of MEM 3454 as Adjunctive Treatment in Combination With a Preexisting Antipsychotic in Patients With Cognitive Impairment Associated With Schizophrenia

Technology Process of Facinicline hydrochloride

There total 5 articles about Facinicline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 677305-02-1
Facinicline hydrochloride

Guidance literature:

Reference yield:

: 6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5
(S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride

: 4498-67-3
1H-Indazole-3-carboxylic acid

: 677305-02-1
Facinicline hydrochloride

Guidance literature:: (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride; 1H-Indazole-3-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 80 ℃; for 4h;

With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 4h;

With hydrogenchloride; In methanol; tert-butyl methyl ether; water; at 5 ℃;

Reference yield:

: 100-63-0
phenylhydrazine

: 677305-02-1
Facinicline hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: water / 3 h / 25 - 30 °C

2.1: dichloromethane / 2 h / 40 °C

3.1: aluminum (III) chloride / dichloromethane / 2 h / 30 °C / Reflux

4.1: hydrogenchloride; acetic acid / water / 1 h / 90 °C

4.2: 0.5 h / 115 °C

5.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 4 h / 80 °C

5.2: 4 h / 70 °C

5.3: 5 °C

With hydrogenchloride; aluminum (III) chloride; thionyl chloride; acetic acid; N,N-dimethyl-formamide; In dichloromethane; water; toluene;