Ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate

Base Information

• Chemical Name: Ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate
• CAS No.: 67752-52-7
• Molecular Formula: C12H13NO3
• Molecular Weight: 219.24
• Mol file: 67752-52-7.mol

Synonyms:2-Oxo-1,2,3,4-tetrahydro-chinolin-4-carbonsaeure-aethylester;2-Oxo-1,2,3,4-tetrahydro-cinchoninsaeure-ethylester;Ethyl-2-oxo-1,2,3,4-tetrahydro-4-chinolincarboxylat;

Chemical Property of Ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate

Chemical Property:

• PSA: 55.40000
• LogP: 1.81350

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate

There total 8 articles about Ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

2-(methyl(phenyl)amino)-2-oxoacetic acid (13120-33-7) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate (67752-52-7) + ethyl 1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate

Guidance literature:

With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; oxygen; In dichloromethane; water; at 30 ℃; for 40h; Irradiation;

DOI:10.1021/acs.orglett.8b00449

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + ethyl 2-hydroxyquinoline-4-carboxylate (5466-27-3) → 4-hydroxymethyl-3,4-dihydro-1H-quinolin-2-one (90097-49-7) + ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate (67752-52-7) + 4-methyl-1,2,3,4-tetrahydroquinoline (19343-78-3,74459-14-6)

Guidance literature:

at 210 - 220 ℃; under 147102 - 220652 Torr; Hydrogenation;

DOI:10.1021/ja01269a048

Reference yield:

2-hydroxyquinoline-4-carboxylic acid (15733-89-8,84906-81-0) → ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylate (67752-52-7)

Guidance literature:

With hydrogenchloride; tin;

upstream raw materials:

2-hydroxyquinoline-4-carboxylic acid

2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid

ethanol

1,4-dioxane

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