1-Bromo-3-(2-bromoethoxy)benzene

Base Information

• Chemical Name: 1-Bromo-3-(2-bromoethoxy)benzene
• CAS No.: 18800-29-8
• Molecular Formula: C8H8Br2O
• Molecular Weight: 279.959
• Hs Code.: 2909309090
• European Community (EC) Number: 851-632-6
• DSSTox Substance ID: DTXSID60368350
• Wikidata: Q82154818
• Mol file: 18800-29-8.mol

Synonyms:1-bromo-3-(2-bromoethoxy)benzene;18800-29-8;1-BROMO-2-(3-BROMOPHENOXY)ETHANE;1-BROMO-2-(3'-BROMOPHENOXY)ETHANE;Benzene,1-bromo-3-(2-bromoethoxy)-;1-BROMO-2-(3/'-BROMOPHENOXY)ETHANE;Enamine_005251;3-(2-Bromoethoxy)bromobenzene;SCHEMBL2298816;DTXSID60368350;CKXSBCXRNZGJJN-UHFFFAOYSA-N;HMS1408O15;MFCD03964543;AKOS000199841;AM86717;GA-0825;IDI1_007838;CS-0213171;FT-0681045;EN300-04759;A880545;J-504408;Z56886268

Chemical Property of 1-Bromo-3-(2-bromoethoxy)benzene

Chemical Property:

• Boiling Point: 291 °C at 760 mmHg
• Flash Point: 116.4 °C
• PSA: 9.23000
• Density: 1.757 g/cm³
• LogP: 3.22280
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 279.89214
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

98%min ^*data from raw suppliers

1-Bromo-2-(3''-bromophenoxy)ethane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Br)OCCBr

Technology Process of 1-Bromo-3-(2-bromoethoxy)benzene

There total 2 articles about 1-Bromo-3-(2-bromoethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-Bromophenol (591-20-8) + ethylene dibromide (106-93-4) → 1-bromo-3-(2-bromoethoxy)benzene (18800-29-8)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 60 ℃;

DOI:10.1021/acs.jmedchem.8b00828

Reference yield:

ethylene dibromide (106-93-4) → 1-bromo-3-(2-bromoethoxy)benzene (18800-29-8)

Guidance literature:

With ethanol;

Reference yield: 78.0%

1-bromo-3-(2-bromoethoxy)benzene (18800-29-8) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → tert-butyl {1-[2-(3-bromophenoxy)ethyl]piperidin-4-yl}carbamate

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 60 ℃; for 24h;

DOI:10.1021/acs.jmedchem.8b00828

upstream raw materials:

3-Bromophenol

ethylene dibromide

Downstream raw materials:

N-[2-(3-bromo-phenoxy)-ethyl]-aniline

[2-(3-bromo-phenoxy)-ethyl]-methyl-amine

[2-(3-bromo-phenoxy)-ethyl]-trimethyl-ammonium; bromide

N-<2-(3-Bromphenoxy)-ethyl>-cyclopropylamin

Refernces

• 1、 Bhagat, Shweta,Arfeen, Minhajul,Adane, Legesse,Singh, Savita,Singh, Prati Pal,Chakraborti, Asit K.,Bharatam, Prasad V.. "Guanylthiourea derivatives as potential antimalarial agents: Synthesis, in?vivo and molecular modelling studies". . p. 339 - 348. Retrieved 2017/05/04.