5-Methoxy-2-phenyl-1,3-dioxane

Base Information

• Chemical Name: 5-Methoxy-2-phenyl-1,3-dioxane
• CAS No.: 104216-84-4
• Molecular Formula: C11H14 O3
• Molecular Weight: 194.23
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID30146349
• Nikkaji Number: J594.571B,J594.572K,J1.512.084C
• Mol file: 104216-84-4.mol

Synonyms:2-M-1,3-OOBG;2-O-methyl-1,3-O,O-benzylideneglycerol

Chemical Property of 5-Methoxy-2-phenyl-1,3-dioxane

Chemical Property:

• Vapor Pressure: 0.00435mmHg at 25°C
• Boiling Point: 287.2°Cat760mmHg
• Flash Point: 95.3°C
• PSA: 27.69000
• Density: 1.11g/cm³
• LogP: 1.74700
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 158

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1COC(OC1)C2=CC=CC=C2

Technology Process of 5-Methoxy-2-phenyl-1,3-dioxane

There total 7 articles about 5-Methoxy-2-phenyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-phenyl-[1,3]dioxan-5-ol (1708-40-3) + methyl iodide (74-88-4) → 5-methoxy-2-phenyl-1,3-dioxane (104216-84-4)

Guidance literature:

2-phenyl-[1,3]dioxan-5-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

methyl iodide; With tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;

Reference yield: 83.0%

dimethyl sulfate (77-78-1) + 2-phenyl-[1,3]dioxan-5-ol (1708-40-3) → 5-methoxy-2-phenyl-1,3-dioxane (104216-84-4)

Guidance literature:

With potassium tert-butylate; In toluene; at 60 ℃;

Reference yield:

dimethyl sulfate (77-78-1) → 5-methoxy-2-phenyl-1,3-dioxane (104216-84-4)

Guidance literature:

With sodium hydroxide; at 30 ℃;

upstream raw materials:

2-phenyl-[1,3]dioxan-5-ol

methyl iodide

dimethyl sulfate

benzaldehyde

Downstream raw materials:

3-(N-methyl octadecylamino)-2-methylcarbamoyloxy-1-trityloxy propane

1-O-benzyl-2-O-methyl-3-O-octadecyl-rac-glycerol

1-O-benzyl-2-O-methyl-3-O-hexadecyl-rac-glycerol

2-methylglycerol

Refernces

• 1、 -. "GLYCEROL DERIVATIVES AND METHODS OF MAKING SAME". Page/Page column 44-45. . Retrieved 2009/01/20.
• 2、 Pinchuk,Mitsner,Shvets. "Synthesis of alkyl glycerophospholipids through 1-o-benzyl-2-o-methyl-rac-glycerol". . p. 174 - 176. Retrieved 2007/10/02.