Cyclohexanol, 2-[1-[4-[[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]oxy]phenyl]-1-meth ylethyl]-5-methyl-, acetate, (1R,2S,5R)-

Base Information

• Chemical Name: Cyclohexanol, 2-[1-[4-[[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]oxy]phenyl]-1-meth ylethyl]-5-methyl-, acetate, (1R,2S,5R)-
• CAS No.: 680580-87-4
• Molecular Formula: C30H52O4Si
• Molecular Weight: 504.826
• Mol file: 680580-87-4.mol

Synonyms:

Chemical Property of Cyclohexanol, 2-[1-[4-[[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]oxy]phenyl]-1-meth ylethyl]-5-methyl-, acetate, (1R,2S,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanol, 2-[1-[4-[[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]oxy]phenyl]-1-meth ylethyl]-5-methyl-, acetate, (1R,2S,5R)-

There total 3 articles about Cyclohexanol, 2-[1-[4-[[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]oxy]phenyl]-1-meth ylethyl]-5-methyl-, acetate, (1R,2S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-(tert-butyldimethylsilyl)oxyhexan-1-ol (103202-59-1) + (-)-8-[(p-methoxy)phenyl]menthyl acetate (680580-83-0) → Acetic acid (1R,2S,5R)-2-(1-{4-[6-(tert-butyl-dimethyl-silanyloxy)-hexyloxy]-phenyl}-1-methyl-ethyl)-5-methyl-cyclohexyl ester (680580-87-4)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2004.01.010

Reference yield:

(-)-8-[(p-methoxy)phenyl]menthol (80868-36-6) → Acetic acid (1R,2S,5R)-2-(1-{4-[6-(tert-butyl-dimethyl-silanyloxy)-hexyloxy]-phenyl}-1-methyl-ethyl)-5-methyl-cyclohexyl ester (680580-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / DMAP; pyridine / 20 °C

2: BBr₃ / CH₂Cl₂ / -78 - -25 °C

3: 90 percent / DIAD; PPh₃ / tetrahydrofuran / 20 °C

With pyridine; dmap; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2004.01.010

Reference yield:

Acetic acid (1R,2S,5R)-2-[1-(4-methoxy-phenyl)-1-methyl-ethyl]-5-methyl-cyclohexyl ester (680580-85-2) → Acetic acid (1R,2S,5R)-2-(1-{4-[6-(tert-butyl-dimethyl-silanyloxy)-hexyloxy]-phenyl}-1-methyl-ethyl)-5-methyl-cyclohexyl ester (680580-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: BBr₃ / CH₂Cl₂ / -78 - -25 °C

2: 90 percent / DIAD; PPh₃ / tetrahydrofuran / 20 °C

With di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2004.01.010

upstream raw materials:

6-(tert-butyldimethylsilyl)oxyhexan-1-ol

(-)-8-[(p-methoxy)phenyl]menthyl acetate

(-)-8-[(p-methoxy)phenyl]menthol

Acetic acid (1R,2S,5R)-2-[1-(4-methoxy-phenyl)-1-methyl-ethyl]-5-methyl-cyclohexyl ester

Downstream raw materials:

Acetic acid (1R,2S,5R)-2-{1-[4-(6-hydroxy-hexyloxy)-phenyl]-1-methyl-ethyl}-5-methyl-cyclohexyl ester