4-Methylstyrylphenyl sulfone

Base Information

• Chemical Name: 4-Methylstyrylphenyl sulfone
• CAS No.: 30166-88-2
• Molecular Formula: C15H14 O2 S
• Molecular Weight: 258.341
• NSC Number: 140160
• Nikkaji Number: J754.128G,J889.400K
• Mol file: 30166-88-2.mol

Synonyms:NSC140160;4-Methylstyrylphenyl sulfone;Phenyl[(E)-4-methylstyryl] sulfone;NSC-140160;30166-88-2

Chemical Property of 4-Methylstyrylphenyl sulfone

Chemical Property:

• Vapor Pressure: 6.89E-08mmHg at 25°C
• Boiling Point: 450.7°Cat760mmHg
• Flash Point: 281.1°C
• Density: 1.194g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 258.07145086
• Heavy Atom Count: 18
• Complexity: 364

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C=CS(=O)(=O)C2=CC=CC=C2
• Isomeric SMILES: CC1=CC=C(C=C1)/C=C/S(=O)(=O)C2=CC=CC=C2

Technology Process of 4-Methylstyrylphenyl sulfone

There total 51 articles about 4-Methylstyrylphenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethyl phenylsulfonylmethylphosphonate (56069-39-7) + 4-methyl-benzaldehyde (104-87-0) → (E)-2-(4-methylphenyl)ethenyl phenyl sulfone (30166-88-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201500562

Reference yield: 98.0%

3-(4-methylphenyl)prop-2-ynoic acid (2227-58-9) + benzenesufonyl hydrazide (80-17-1) → (E)-2-(4-methylphenyl)ethenyl phenyl sulfone (30166-88-2)

Guidance literature:

With copper(I) oxide; In tetrahydrofuran; at 80 ℃; for 24h;

Reference yield: 93.0%

1-ethenyl-4-methylbenzene (622-97-9,24936-41-2) + 1,2-bis(benzenesulfonyl)hydrazine (6272-36-2) → (E)-2-(4-methylphenyl)ethenyl phenyl sulfone (30166-88-2)

Guidance literature:

With N-iodo-succinimide; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

DOI:10.1016/j.tet.2020.131019

upstream raw materials:

α,α-bis(trimethylsilyl)methylphenyl sulfide

4-methyl-benzaldehyde

1-ethenyl-4-methylbenzene

benzenesulfonyl chloride

Downstream raw materials:

1-((1S,2R)-2-Benzenesulfonyl-cyclopropyl)-4-methyl-benzene

2-[(E)-2-(4-methylphenyl)ethenyl]tetrahydrofuran

(Z)-1-methyl-4-[2-(phenylsulfanyl)ethenyl]benzene

(E)-1-methyl-4-[2-(phenylsulfanyl)ethenyl]benzene

Refernces

• 1、 Guo, Yuan-Qiang,Wang, Kaihua,Wang, Ruiguo,Song, Hongjian,Liu, Yuxiu,Wang, Qingmin. "Visible-Light-Induced Three-Component Intermolecular Trifluoromethyl-Alkenylation Reactions of Unactivated Alkenes". supporting information. p. 1651 - 1655. Retrieved 2021/02/12.
• 2、 An, Seunghwan,Lee, Sunwoo,Song, Kwang Ho. "Vinyl sulfone synthesisviacopper-catalyzed three-component decarboxylative addition". supporting information. p. 7827 - 7831. Retrieved 2021/09/28.