4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2,2,2-trichloroethoxy)carbonyl]thio]-, diphenylmethyl ester, (2S,5R,6R)-

Base Information

Chemical Name:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2,2,2-trichloroethoxy)carbonyl]thio]-, diphenylmethyl ester, (2S,5R,6R)-
CAS No.:683751-09-9
Molecular Formula:C24H22Cl3NO5S2
Molecular Weight:574.933
Hs Code.:

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,
3,3-dimethyl-7-oxo-6-[[(2,2,2-trichloroethoxy)carbonyl]thio]-,
diphenylmethyl ester, (2S,5R,6R)-

Synonyms:

Suppliers and Price of 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2,2,2-trichloroethoxy)carbonyl]thio]-, diphenylmethyl ester, (2S,5R,6R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2,2,2-trichloroethoxy)carbonyl]thio]-, diphenylmethyl ester, (2S,5R,6R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2,2,2-trichloroethoxy)carbonyl]thio]-, diphenylmethyl ester, (2S,5R,6R)-

There total 6 articles about 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[[(2,2,2-trichloroethoxy)carbonyl]thio]-, diphenylmethyl ester, (2S,5R,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 683751-05-5
(2S,5R,6R)-6-Mercapto-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 683751-09-9
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

Guidance literature:: With dmap; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2003.12.037

Reference yield:

: 551-16-6
6-Aminopenicillanic Acid

: 683751-09-9
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaNO₂; aq. HClO₄

2: Et₃N

3: acetonitrile

4: 80 percent / NaOMe / tetrahydrofuran; methanol / 8 h / -78 °C

5: 73 percent / DMAP / 3 h / 0 - 20 °C

With dmap; perchloric acid; sodium methylate; triethylamine; sodium nitrite; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/j.bmcl.2003.12.037

Reference yield:

: 15058-64-7
6-α-hydroxypenicillanic acid

: 683751-09-9
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2,2,2-trichloro-ethoxycarbonylsulfanyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N

2: acetonitrile

3: 80 percent / NaOMe / tetrahydrofuran; methanol / 8 h / -78 °C

4: 73 percent / DMAP / 3 h / 0 - 20 °C

With dmap; sodium methylate; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/j.bmcl.2003.12.037