2,4-Dichloro-6-ethynylaniline

Base Information

Chemical Name:2,4-Dichloro-6-ethynylaniline
CAS No.:684250-09-7
Molecular Formula:C8H5Cl2N
Molecular Weight:186.04
Hs Code.:
DSSTox Substance ID:DTXSID30478571
Nikkaji Number:J2.019.449I

Synonyms:2,4-Dichloro-6-ethynylaniline;684250-09-7;2,4-DICHLORO-6-ETHYNYL-PHENYLAMINE;DTXSID30478571;AKOS006239031

Suppliers and Price of 2,4-Dichloro-6-ethynylaniline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2,4-Dichloro-6-ethynylaniline

Chemical Property:

Vapor Pressure:0.00267mmHg at 25°C
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:184.9799046
Heavy Atom Count:11
Complexity:184

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C#CC1=C(C(=CC(=C1)Cl)Cl)N

Technology Process of 2,4-Dichloro-6-ethynylaniline

There total 3 articles about 2,4-Dichloro-6-ethynylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 684250-19-9
2,4-dichloro-6-trimethylsilanylethynylaniline

: 684250-09-7
2,4-dichloro-6-ethynylphenylamine

Guidance literature:: With potassium fluoride; In methanol; at 20 ℃; for 3h;
DOI:10.1055/s-2004-815947

Reference yield:

: 697-86-9
2,4-dichloro-6-bromoaniline

: 684250-09-7
2,4-dichloro-6-ethynylphenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Et₃N / PdCl₂(PPh₃)2; CuI / dimethylformamide / 8 h / 50 °C

2: 86 percent / KF / methanol / 3 h / 20 °C

With potassium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In methanol; N,N-dimethyl-formamide; 1: Sonogashira reaction;
DOI:10.1055/s-2004-815947

Reference yield:

: 697-90-5
2,4-dichloro-6-iodoaniline

: 684250-09-7
2,4-dichloro-6-ethynylphenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 20 °C

2: potassium carbonate; methanol / 2 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine;
DOI:10.1039/c4cc03565h