2-Chloro-4-(dimethylamino)benzaldehyde

Base Information

• Chemical Name: 2-Chloro-4-(dimethylamino)benzaldehyde
• CAS No.: 1424-66-4
• Molecular Formula: C9H10 Cl N O
• Molecular Weight: 183.637
• Hs Code.: 2922399090
• European Community (EC) Number: 215-840-5
• NSC Number: 93918
• DSSTox Substance ID: DTXSID8061686
• Nikkaji Number: J298.612D
• Wikidata: Q81989599
• Mol file: 1424-66-4.mol

Synonyms:2-Chloro-4-(dimethylamino)benzaldehyde;1424-66-4;Benzaldehyde, 2-chloro-4-(dimethylamino)-;2-Chloro-4-dimethylaminobenzaldehyde;EINECS 215-840-5;NSC 93918;Benzaldehyde, 2-chloro-4-dimethylamino-;NSC93918;SCHEMBL1002405;DTXSID8061686;4-Nitrophenyl)methyl 3-oxobutanoate;MFCD00021051;NSC-93918;AKOS006229424;PS-4349;NCGC00188271-01;C2606;CS-0206315;FT-0611737;T70273;2-chloro-4-(dimethylamino)benzaldehyde, AldrichCPR

Chemical Property of 2-Chloro-4-(dimethylamino)benzaldehyde

Chemical Property:

• Vapor Pressure: 0.000642mmHg at 25°C
• Melting Point: 70-73oC
• Boiling Point: 309.4°Cat760mmHg
• Flash Point: 140.9°C
• PSA: 20.31000
• Density: 1.215g/cm³
• LogP: 2.21850
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 183.0450916
• Heavy Atom Count: 12
• Complexity: 161

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-4-(dimethylamino)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-52-43-36
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=CC(=C(C=C1)C=O)Cl
• Uses: 2-Chloro-4-(dimethylamino)benzaldehyde is a useful reagent in the preparation of arylidenaminoguanidine derivatives with antihypertensive activity.

Technology Process of 2-Chloro-4-(dimethylamino)benzaldehyde

There total 4 articles about 2-Chloro-4-(dimethylamino)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-N,N-dimethylaniline (6848-13-1) → 2-chloro-4-(dimethylamino)benzaldehyde (1424-66-4)

Guidance literature:

With hydrogenchloride; formaldehyd; 4-nitroso-N,N-dimethylaniline hydrochloride; man faellt mit Soda und kocht die erhaltene Verbindung in einem Gemisch von Alkohol und Eisessig mit Formaldehydloesung;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-chloro-N,N-dimethylaniline (6848-13-1) → 2-chloro-4-(dimethylamino)benzaldehyde (1424-66-4)

Guidance literature:

With 4-hydroxyl-amino-toluene-sulfonic acid-⁽²⁾; iron(II) sulfate; Verseifung des Reaktionsprodukts mit konzentrierter Natronlauge;

Reference yield:

chloral hydrate (302-17-0) + 3-chloro-N,N-dimethylaniline (6848-13-1) → 2-chloro-4-(dimethylamino)benzaldehyde (1424-66-4)

Guidance literature:

Spalten mit alkoh. Kali;

upstream raw materials:

formaldehyd

3-chloro-N,N-dimethylaniline

chloral hydrate

Downstream raw materials:

{3-Chloro-4-[(E)-octyliminomethyl]-phenyl}-dimethyl-amine

Di-(chlor-2-dimethylamino-4-phenyl)-1,2-ethylen

(5Z)-3-(4-bromobenzyl)-5-(2-chloro-4-dimethylaminobenzylidene)-5H-furan-2-one

(2-chloro-4-dimethylamino-benzylidene)-malononitrile

Refernces

• 1、 -. "Novel compounds, processes and marking systems". . . Retrieved 2008/06/13.