1-(2-Hydroxyethoxy)methyl-5-methyluracil

Base Information

• Chemical Name: 1-(2-Hydroxyethoxy)methyl-5-methyluracil
• CAS No.: 68724-11-8
• Molecular Formula: C8H12N2O4
• Molecular Weight: 200.194
• Hs Code.: 2933599090
• Mol file: 68724-11-8.mol

Synonyms:1-[(2-OHEtO)Me]T;1-[(2-hydroxyethoxy)methyl]-5-methyl-2,4(1H,3H)-pyrimidinedione;1-(2-hydroxyethoxymethyl)-5-methyl-pyrimidine-2,4-dione;1-<(2-hydroxyethoxy)methyl>-5-methyluracil;1-((2-hydroxyethoxy)methyl)-5-methylpyrimidine-2,4(1H,3H)-dione;acyclothymidine;5-methyl-1-(2'-hydroxyethoxymethyl)uracil;1-<(2-hydroxyethoxy)methyl>thymine;

Chemical Property of 1-(2-Hydroxyethoxy)methyl-5-methyluracil

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 84.32000
• Density: 1.285g/cm³
• LogP: -1.18860
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

1-((2-Hydroxyethoxy)methyl)-5-methylpyrimidine-2,4(1H,3H)-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Hydroxyethoxy)methyl-5-methyluracil

There total 11 articles about 1-(2-Hydroxyethoxy)methyl-5-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-<<2-(benzoyloxy)ethoxy>methyl>-5-methyluracil (78097-06-0) → 1-[(2-hydroxyethoxy)methyl]thymine (68724-11-8)

Guidance literature:

With ammonia; In methanol; at 4 - 5 ℃; for 120h;

DOI:10.1021/jm00141a012

Reference yield: 93.0%

1-<(2-acetoxyethoxy)methyl>thymine (81777-42-6) → 1-[(2-hydroxyethoxy)methyl]thymine (68724-11-8)

Guidance literature:

With sodium; In methanol; for 2h; Ambient temperature;

DOI:10.1139/v82-081

Reference yield: 86.0%

1-<<2-(benzoyloxy)ethoxy>methyl>-5-methyluracil (78097-06-0) + methylamine (74-89-5) → N-methylbenzamide (88070-48-8) + 1-[(2-hydroxyethoxy)methyl]thymine (68724-11-8)

Guidance literature:

With water; at 50 ℃; for 3h;

upstream raw materials:

1,2-dihydro-5-methyl-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine

1-<<2-(benzoyloxy)ethoxy>methyl>-5-methyluracil

1-<(2-acetoxyethoxy)methyl>thymine

(2-benzoyloxyethyl)oxymethyl chloride

Downstream raw materials:

5-methyl-1-(2'-O-p-tolylsulfonylethoxymethyl)uracil

2-[(5-methyluracil-1-yl)methoxy]-ethyl N-[(benzyloxy)carbonyl]-L-valinate

Toluene-4-sulfonic acid 2-[5-methyl-2,4-dioxo-6-(pyridin-2-ylsulfanyl)-3,4-dihydro-2H-pyrimidin-1-ylmethoxy]-ethyl ester

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)thymine

Refernces

• 1、 Meng, Ge,Kuang, Yun-Yan,Ji, Lei,Chen, Fen-Er. "Synthesis of 1-[(2-hydroxyethoxy)methyl] 6-(5,6,7,8- tetrahydronaphthylmethyl-1) thymine as novel inhibitor against drug-resistant HIV mutants". . p. 1095 - 1102. Retrieved 2005.
• 2、 Van Daele, Ineke,Munier-Lehmann, Hélène,Froeyen, Matheus,Balzarini, Jan,Van Calenbergh, Serge. "Rational design of 5′-thiourea-substituted α-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth". . p. 5281 - 5292. Retrieved 2008/03/14.
• 3、 Eriksson, Andre H.,Elm, Peter L.,Begtrup, Mikael,Brodin, Birger,Nielsen, Robert,Steffansen, Bente. "Pyrimidine and nucleoside γ-esters of L-Glu-Sar: Synthesis, stability and interaction with hPEPT1". . p. 145 - 154. Retrieved 2007/10/03.