3-(6-AMINO-8-BROMO-9H-PURIN-9-YL)PROPANE-1,2-DIOL

Base Information

• Chemical Name: 3-(6-AMINO-8-BROMO-9H-PURIN-9-YL)PROPANE-1,2-DIOL
• CAS No.: 69369-04-6
• Molecular Formula: C₈H₁₀BrN₅O₂
• Molecular Weight: 288.104
• Mol file: 69369-04-6.mol

Synonyms:8-bromo-9-(2,3-dihydroxypropyl)-9H-adenine;3-(6-amino-8-bromo-purin-9-yl)-propane-1,2-diol;9-(RS)-(2,3-Dihydroxypropyl)-8-bromadenin;8-bromo-9-(2,3-dihydroxypropyl)adenine;

Chemical Property of 3-(6-AMINO-8-BROMO-9H-PURIN-9-YL)PROPANE-1,2-DIOL

Chemical Property:

• PSA: 110.08000
• LogP: 0.10540

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

Technology Process of 3-(6-AMINO-8-BROMO-9H-PURIN-9-YL)PROPANE-1,2-DIOL

There total 4 articles about 3-(6-AMINO-8-BROMO-9H-PURIN-9-YL)PROPANE-1,2-DIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

9-(2,3-dihydroxypropyl)adenine (716-17-6,54262-83-8,55559-72-3,55904-02-4) → 9-(RS)-(2,3-dihydroxypropyl)-8-bromoadenine (69369-04-6)

Guidance literature:

With bromine; In water; Ambient temperature; stoppered flask;

Reference yield:

oxiranyl-methanol (556-52-5) + 8-bromoadenine (6974-78-3) → 9-(RS)-(2,3-dihydroxypropyl)-8-bromoadenine (69369-04-6) + 8-bromo-3-(2,3-dihydroxypropyl)adenine (169776-86-7)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) DMF, 85 deg C, 2.) DMF, 85 deg C, 8 h;

Reference yield:

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → 9-(RS)-(2,3-dihydroxypropyl)-8-bromoadenine (69369-04-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / NaOH / dimethylformamide

2: 63 percent / bromine / H₂O / 24 h / Ambient temperature

With sodium hydroxide; bromine; In water; N,N-dimethyl-formamide;

upstream raw materials:

9-(2,3-dihydroxypropyl)adenine

oxiranyl-methanol

8-bromoadenine

adenine

Downstream raw materials:

4-amino-8,9-dihydro-7H-[1,3]oxazino[3,2-e]purin-8-ol

9-(2,3-dihydroxypropyl)adenine

C₂₂H₂₃N₅O₇S₂

Toluene-4-sulfonic acid 3-(6-amino-8-hydroxy-purin-9-yl)-2-hydroxy-propyl ester