1-(Morpholin-4-yl)prop-2-yn-1-one

Base Information

• Chemical Name: 1-(Morpholin-4-yl)prop-2-yn-1-one
• CAS No.: 72431-18-6
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• DSSTox Substance ID: DTXSID30511194
• Nikkaji Number: J2.869.491A
• Wikidata: Q82369877
• Mol file: 72431-18-6.mol

Synonyms:1-(Morpholin-4-yl)prop-2-yn-1-one;72431-18-6;1-morpholinoprop-2-yn-1-one;1-morpholin-4-ylprop-2-yn-1-one;Morpholine, 4-(1-oxo-2-propynyl)-;SCHEMBL7089526;DTXSID30511194;MWLRHVKMEDRDMI-UHFFFAOYSA-N;AKOS026705676;AB91295;DY-0058;F8885-5715

Chemical Property of 1-(Morpholin-4-yl)prop-2-yn-1-one

Chemical Property:

• Boiling Point: 227.2±50.0 °C(Predicted)
• PSA: 29.54000
• Density: 1.158±0.06 g/cm3(Predicted)
• LogP: -0.58370
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 173

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(morpholin-4-yl)prop-2-yn-1-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C#CC(=O)N1CCOCC1

Technology Process of 1-(Morpholin-4-yl)prop-2-yn-1-one

There total 7 articles about 1-(Morpholin-4-yl)prop-2-yn-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(morpholin-4-yl)-3-trimethylsilylprop-2-yn-1-one → 1-(morpholin-4-yl)prop-2-yn-1-one (72431-18-6)

Guidance literature:

With KF-Al₂O₃ (5 mol percent); In methanol; at 25 ℃; for 0.333333h;

DOI:10.1134/S1070428011120037

Reference yield: 75.0%

morpholine (110-91-8,99108-56-2) + Propiolic acid (471-25-0) → 1-(morpholin-4-yl)prop-2-yn-1-one (72431-18-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/d0cc05706a

Reference yield:

4-morpholinocarbonyl chloride (15159-40-7) → 1-(morpholin-4-yl)prop-2-yn-1-one (72431-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / 0 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium carbonate / water; methanol / 0.5 h

With n-butyllithium; sodium carbonate; In tetrahydrofuran; methanol; hexane; water;

DOI:10.1016/j.ejmech.2019.111800

upstream raw materials:

morpholine

Propiolic acid

methanol

methylamine

Downstream raw materials:

ethyl 1,4-cyclohexadiene-1-carboxylate