1,2,3-Cyclopropanetricarboxylic acid, triethyl ester

Base Information

• Chemical Name: 1,2,3-Cyclopropanetricarboxylic acid, triethyl ester
• CAS No.: 729-87-3
• Molecular Formula: C₁₂H₁₈O₆
• Molecular Weight: 258.271
• Mol file: 729-87-3.mol

Synonyms:

Chemical Property of 1,2,3-Cyclopropanetricarboxylic acid, triethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3-Cyclopropanetricarboxylic acid, triethyl ester

There total 16 articles about 1,2,3-Cyclopropanetricarboxylic acid, triethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

diazoacetic acid ethyl ester (623-73-4) + Diethyl maleate (141-05-9) → triethyl trans-1,2,3-cyclopropanetricarboxylate (729-87-3,13950-16-8)

Guidance literature:

dmap; In chlorobenzene; at 20 ℃; for 20h;

DOI:10.1021/ja074613o

Reference yield: 65.0%

ethyl bromoacetate (105-36-2) → (E)-Cyclopropan-1,2,3-tricarbonsaeuretriethylester (729-87-3,13950-16-8)

Guidance literature:

With hexaphenylcarbodiphosphorane; In benzene; for 20h; Heating;

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + ethene (74-85-1) → (E)-Cyclopropan-1,2,3-tricarbonsaeuretriethylester (729-87-3,13950-16-8)

Guidance literature:

With chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I); silver trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 14h; under 6000.6 Torr; Inert atmosphere; Schlenk technique;

DOI:10.3762/bjoc.15.7

upstream raw materials:

diazoacetic acid ethyl ester

ethyl bromoacetate

3,4,5-triethyl 4,5-dihydro-1H-pyrazole-3,4,5-tricarboxylate

Diethyl maleate

Downstream raw materials:

cyclopropane-1r,2,3t-tricarboxylic acid

cyclopropane-1r,2,3t-tricarboxylic acid trimethyl ester

1trans,2trans,3ref-Tris-(diphenylhydroxymethyl)-cyclopropan

trans-1,2,3-Tris-(acetoxymethyl)-cyclopropan