Chemical Property of Merimepodib
Chemical Property:
- Vapor Pressure:4.58E-13mmHg at 25°C
- Boiling Point:571.4°Cat760mmHg
- PKA:11.66±0.46(Predicted)
- Flash Point:299.4°C
- PSA：130.93000
- Density:1.36g/cm3
- LogP:4.30030
- Storage Temp.:Sealed in dry,Room Temperature
- Solubility.:≥45.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
- XLogP3:2.1
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:8
- Exact Mass:452.16958450
- Heavy Atom Count:33
- Complexity:652
- Purity/Quality:
-
99%, *data from raw suppliers
Merimepodib >98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:COC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)OC3CCOC3)C4=CN=CO4
- Isomeric SMILES:COC1=C(C=CC(=C1)NC(=O)NC2=CC=CC(=C2)CNC(=O)O[C@H]3CCOC3)C4=CN=CO4
- Recent ClinicalTrials:Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19
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Description
Merimepodib is an inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Kis = 7 and 10 nM for IMPDH type I and type II, respectively) with antiviral and immunosuppressant activities. It reduces Ebola, Lassa, chikungunya, Junin, and Zika virus titers in vitro and inhibits Zika virus replication in Huh7 cells (EC50 = 0.6 μM). Merimepodib inhibits the proliferation of PHA-stimulated T cells and SPAS-stimulated B cells (IC50s = 104 and 132 nM, respectively), effects that can be reversed by guanosine but not adenosine . In vivo, merimepodib (50 and 100 mg/kg) increases allograft survival in a murine skin transplantation model and prevents development of graft versus host disease (GVHD) in splenocyte allografted mice.
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Uses
Inhibition of inosine monophosphate dehydrogenase (IMPDH), which has potential
antiviral, antiproliferative, antiparasitic, and immunosuppressive activity.
