N2-Methylpyridine-2,6-diaMine

Base Information

• Chemical Name: N2-Methylpyridine-2,6-diaMine
• CAS No.: 75135-46-5
• Molecular Formula: C6H9N3
• Molecular Weight: 123.158
• Hs Code.: 2933399090
• Mol file: 75135-46-5.mol

Synonyms:2-Amino-6-methylaminopyridine;2,6-PYRIDINEDIAMINE,N-METHYL;2-methylamino-6-aminopyridine;N2-Methylpyridine-2,6-diamine;

Chemical Property of N2-Methylpyridine-2,6-diaMine

Chemical Property:

• PSA: 51.67000
• LogP: 0.70860
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N2-Methylpyridine-2,6-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N2-Methylpyridine-2,6-diaMine

There total 4 articles about N2-Methylpyridine-2,6-diaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + methylamine (74-89-5) → 2-Amino-6-methylaminopyridine (75135-46-5)

Guidance literature:

With copper(l) iodide; In water; at 160 ℃; for 5h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.tet.2015.08.042

Reference yield: 56.0%

2-(N-methylamino)pyridine (4597-87-9) → 2-Amino-6-methylaminopyridine (75135-46-5)

Guidance literature:

With sodium amide; In mineral oil; at 20 - 215 ℃;

DOI:10.1016/j.tetlet.2015.12.013

Reference yield: 10.0%

2.6-diaminopyridine (141-86-6) + methyl iodide (74-88-4) → 2-Amino-6-methylaminopyridine (75135-46-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

6-chloropyridin-2-amine

methylamine

2.6-diaminopyridine

methyl iodide

Refernces

• 1、 Mastalir, Matthias,Rosenberg, Egon E.,Kirchner, Karl. "A practical synthesis of substituted 2,6-diaminopyridines via microwave-assisted copper-catalyzed amination of halopyridines". . p. 8104 - 8110. Retrieved 2015/12/30.
• 2、 -. "QUINAZOLINE DERIVATIVES". Page/Page column 132-133. . Retrieved 2008/06/13.