Diphenyl 1-phenylethyl phosphate

Base Information

• Chemical Name: Diphenyl 1-phenylethyl phosphate
• CAS No.: 76263-88-2
• Molecular Formula: C20H19O4P
• Molecular Weight: 354.342
• DSSTox Substance ID: DTXSID50504447
• Nikkaji Number: J636.186B
• Mol file: 76263-88-2.mol

Synonyms:Diphenyl 1-phenylethyl phosphate;76263-88-2;1-phenylethyl diphenyl phosphate;DTXSID50504447

Chemical Property of Diphenyl 1-phenylethyl phosphate

Chemical Property:

• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 354.10209608
• Heavy Atom Count: 25
• Complexity: 399

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)OP(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3

Technology Process of Diphenyl 1-phenylethyl phosphate

There total 6 articles about Diphenyl 1-phenylethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-Phenylethanol (98-85-1,13323-81-4) + chlorophosphoric acid diphenyl ester (2524-64-3) → (+/-)-1-phenylethyl diphenyl phosphate (76263-88-2)

Guidance literature:

With dmap; In dichloromethane; Ambient temperature;

Reference yield: 23.0%

2-bromo-1-phenylethyl diphenyl phosphate → 2-phenylethyl diphenyl phosphate (66910-78-9) + (+/-)-1-phenylethyl diphenyl phosphate (76263-88-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 2h; Heating;

Reference yield:

[(4R)-4-benzyl-2-oxo-oxazolidin-3-yl]-phosphonic acid diphenyl ester + 1-Phenylethanol (98-85-1,13323-81-4) → bis(1-phenylethyl)ether (93-96-9) + (R)-4-(phenylmethyl)-2-oxazolidinone (40217-17-2,90719-32-7,120574-96-1,102029-44-7) + (1-bromoethyl)benzne (585-71-7,38661-81-3) + (+/-)-1-phenylethyl diphenyl phosphate (76263-88-2)

Guidance literature:

1-Phenylethanol; With methylmagnesium bromide; In diethyl ether; at -78 - 20 ℃;

[(4R)-4-benzyl-2-oxo-oxazolidin-3-yl]-phosphonic acid diphenyl ester; In diethyl ether; dichloromethane; at 20 ℃; for 19h;

DOI:10.1016/j.tetasy.2005.08.025

upstream raw materials:

1-Phenylethanol

chlorophosphoric acid diphenyl ester

2-Bromo-1-phenylethanol

Downstream raw materials:

tert-butyl 2-methylene-4-phenylpentanoate

bis(1-phenylethyl)ether

1,1,2-Triphenylpropane

9-(1-phenylethyl)-9H-fluorene