8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one

Base Information

Chemical Name:8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one
CAS No.:77779-90-9
Molecular Formula:C17H13N3O
Molecular Weight:275.31
Hs Code.:
ChEMBL ID:CHEMBL4250570
DSSTox Substance ID:DTXSID10414932
Nikkaji Number:J1.060.926G
Wikidata:Q82224025

Synonyms:8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one;SCHEMBL1467162;CHEMBL4250570;DTXSID10414932;FRRTVUKUZHKCGW-UHFFFAOYSA-N;AKOS002682355;BB 0221370;8-methyl-2-phenyl-5H-pyrazolo[4,3-c]quinolin-3-one;8-Methyl-2-phenyl-1,2-dihydro-pyrazolo[4,3-c ]quinolin-3-one

Suppliers and Price of 8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:275.105862047
Heavy Atom Count:21
Complexity:407

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C3C(=CN=C2C=C1)C(=O)N(N3)C4=CC=CC=C4

Technology Process of 8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one

There total 6 articles about 8-Methyl-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 59-88-1
phenylhydrazine hydrochloride

: 56824-87-4
ethyl 4-chloro-6-methylquinoline-3-carboxylate

: 77779-90-9
8-methyl-2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 0.0166667h;
DOI:10.1080/14756366.2017.1404592

Reference yield: 78.0%

: 100-63-0
phenylhydrazine

: 56824-87-4
ethyl 4-chloro-6-methylquinoline-3-carboxylate

: 77779-90-9
8-methyl-2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one

Guidance literature:: phenylhydrazine; ethyl 4-chloro-6-methylquinoline-3-carboxylate; In toluene; for 3h;

With acetic acid; for 2h; Heating;
DOI:10.1081/NCN-120038009

Reference yield:

: 79607-24-2,85418-82-2
6-methyl-4-carbonylquinoline-3-carboxylic acid ethyl ester

: 77779-90-9
8-methyl-2-phenyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 17 h / Heating

2.1: toluene / 3 h

2.2: 78 percent / acetic acid / 2 h / Heating

With thionyl chloride; In toluene;
DOI:10.1081/NCN-120038009