Propanedioic acid, [(4E,6E)-1,5-dimethyl-3-(phenylsulfonyl)-7-(2,6,6-trimethyl-1-cyclohexen -1-yl)-4,6-heptadienylidene]-, diethyl ester

Base Information

• Chemical Name: Propanedioic acid, [(4E,6E)-1,5-dimethyl-3-(phenylsulfonyl)-7-(2,6,6-trimethyl-1-cyclohexen -1-yl)-4,6-heptadienylidene]-, diethyl ester
• CAS No.: 777916-02-6
• Molecular Formula: C31H42O6S
• Molecular Weight: 542.737
• Mol file: 777916-02-6.mol

Synonyms:

Chemical Property of Propanedioic acid, [(4E,6E)-1,5-dimethyl-3-(phenylsulfonyl)-7-(2,6,6-trimethyl-1-cyclohexen -1-yl)-4,6-heptadienylidene]-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, [(4E,6E)-1,5-dimethyl-3-(phenylsulfonyl)-7-(2,6,6-trimethyl-1-cyclohexen -1-yl)-4,6-heptadienylidene]-, diethyl ester

There total 3 articles about Propanedioic acid, [(4E,6E)-1,5-dimethyl-3-(phenylsulfonyl)-7-(2,6,6-trimethyl-1-cyclohexen -1-yl)-4,6-heptadienylidene]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diethyl bromoisopropylidenemalonate (13830-91-6) + 5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene (38987-91-6) → 2-[(4E,6E)-3-Benzenesulfonyl-1,5-dimethyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienylidene]-malonic acid diethyl ester (777916-02-6) + 2-[(2E,4E)-1-Benzenesulfonyl-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienyl]-2-methyl-cyclopropane-1,1-dicarboxylic acid diethyl ester (777916-04-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2004.07.146

Reference yield: 74.0%

diethyl bromoisopropylidenemalonate (13830-91-6) + 5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene (38987-91-6) → 2-[(4E,6E)-3-Benzenesulfonyl-1,5-dimethyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienylidene]-malonic acid diethyl ester (777916-02-6)

Guidance literature:

5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

diethyl bromoisopropylidenemalonate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h;

DOI:10.1055/s-2004-834867

Reference yield: 20.0%

Methyl-chlormethyl-methylenmalonsaeurediaethylester (41589-50-8) + 5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene (38987-91-6) → 2-[(4E,6E)-3-Benzenesulfonyl-1,5-dimethyl-7-(2,6,6-trimethyl-cyclohex-1-enyl)-hepta-4,6-dienylidene]-malonic acid diethyl ester (777916-02-6) + 2-[(2E,4E)-1-Benzenesulfonyl-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienyl]-2-methyl-cyclopropane-1,1-dicarboxylic acid diethyl ester (777916-04-8)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.07.146

upstream raw materials:

diethyl bromoisopropylidenemalonate

5-(2,6,6-trimethyl-cyclohex-1-enyl)-3-methyl-1-phenyl-sulphonyl-penta-2,4-diene

Methyl-chlormethyl-methylenmalonsaeurediaethylester

Downstream raw materials:

all-trans-retinoic-acid

13-cis-retinoic acid

acide-2-carboxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2E,4E,6E,8E-tetraenoique