2-methoxy-N-methylbenzamide

Base Information

• Chemical Name: 2-methoxy-N-methylbenzamide
• CAS No.: 3400-35-9
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID60187609
• Nikkaji Number: J54.821I
• Wikidata: Q83059316
• Mol file: 3400-35-9.mol

Synonyms:2-methoxy-N-methylbenzamide;3400-35-9;Benzamide, o-methoxy-N-methyl-;o-Methoxy-N-methylbenzamide;BRN 2638881;o-Anisamide, N-methyl-;N-methyl-2-methoxybenzamide;o-methoxy-n -methylbenzamide;SCHEMBL353828;Benzamide, 2-methoxy-N-methyl-;DTXSID60187609;MFCD01578285;AKOS008932896;LS-27103;FT-0707261;Z32016372

Chemical Property of 2-methoxy-N-methylbenzamide

Chemical Property:

• Vapor Pressure: 0.000569mmHg at 25°C
• Boiling Point: 311.3°Cat760mmHg
• PKA: 15.12±0.46(Predicted)
• Flash Point: 142.1°C
• PSA: 41.82000
• Density: 1.074g/cm³
• LogP: 1.62960
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 165.078978594
• Heavy Atom Count: 12
• Complexity: 159

Purity/Quality:

90% ^*data from raw suppliers

2-METHOXY-N-METHYLBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)C1=CC=CC=C1OC

Technology Process of 2-methoxy-N-methylbenzamide

There total 12 articles about 2-methoxy-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

methanol (67-56-1) + 2‐fluoro‐N‐methylbenzamide (52833-63-3) → 2-methoxy-N-methylbenzamide (3400-35-9)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2017.11.067

Reference yield: 53.0%

N-Methylformamide (123-39-7) + 2-bromoanisole (578-57-4) → 2-methoxy-N-methylbenzamide (3400-35-9)

Guidance literature:

With tris(2,4-di-tert-butylphenyl)phosphite; sodium methylate; nickel(II) acetate tetrahydrate; In diethylene glycol dimethyl ether; at 110 ℃; for 10h;

DOI:10.1021/jo901065y

Reference yield: 52.0%

methanol (67-56-1) + 2-methoxybenzamide (2439-77-2) → 2-methoxy-N-methylbenzamide (3400-35-9)

Guidance literature:

With C₅₄H₄₃ClN₃P₂Ru⁽¹⁺⁾*F₆P^(1-); caesium carbonate; In toluene; at 150 ℃; for 48h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.9b01925

upstream raw materials:

N-methylsalicylamide

methyl bromide

2-Methoxybenzoic acid

methylamine

Downstream raw materials:

2-((R)-2-Hydroxy-pentadecyl)-6-methoxy-N-methyl-benzamide

2-((S)-2-Hydroxy-pentadecyl)-6-methoxy-N-methyl-benzamide

2-(2-Hydroxy-propyl)-6-methoxy-N-methyl-benzamide

N-methyl-N-<(trimethylsilyl)methyl>-2-methoxybenzamide