2-Fluoro-4,5-dimethoxybenzoic acid

Base Information

• Chemical Name: 2-Fluoro-4,5-dimethoxybenzoic acid
• CAS No.: 79474-35-4
• Molecular Formula: C9H9FO4
• Molecular Weight: 200.16400
• Hs Code.: 2918990090
• Mol file: 79474-35-4.mol

Synonyms:6-fluoroveratric acid;Benzoic acid,2-fluoro-4,5-dimethoxy;

Chemical Property of 2-Fluoro-4,5-dimethoxybenzoic acid

Chemical Property:

• Boiling Point: 295.9±35.0 °C(Predicted)
• PKA: 3.42±0.10(Predicted)
• PSA: 55.76000
• Density: 1.298±0.06 g/cm3(Predicted)
• LogP: 1.54110
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4,5-dimethoxybenzoic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-4,5-dimethoxybenzoic acid

There total 5 articles about 2-Fluoro-4,5-dimethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-fluoro-4,5-dimethoxybenzaldehyde (71924-62-4) → 2-fluoro-4,5-dimethoxybenzoic acid (79474-35-4)

Guidance literature:

With potassium permanganate; In water; for 1h; Heating;

DOI:10.1016/0022-1139(95)90108-T

Reference yield:

4-fluoroveratrole (398-62-9) → 2-fluoro-4,5-dimethoxybenzoic acid (79474-35-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 84.5 percent / AlCl₃ / 1,2-dichloro-ethane / 2.5 h / -20 - 20 °C

2: 89 percent / Br₂ / CHCl₃ / 2 h / Ambient temperature

3: 1.) diethylamine, 2.) conc. HCl / 1.) i-Pr-OH, RT, 6 h, 2.) i-PrOH

With hydrogenchloride; aluminium trichloride; bromine; diethylamine; In chloroform; 1,2-dichloro-ethane;

Reference yield:

1-(2-fluoro-4,5-dimethoxyphenyl)ethanone (142265-69-8) → 2-fluoro-4,5-dimethoxybenzoic acid (79474-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Br₂ / CHCl₃ / 2 h / Ambient temperature

2: 1.) diethylamine, 2.) conc. HCl / 1.) i-Pr-OH, RT, 6 h, 2.) i-PrOH

With hydrogenchloride; bromine; diethylamine; In chloroform;

upstream raw materials:

2-Bromo-1-(2-fluoro-4,5-dimethoxy-phenyl)-ethanone

2-fluoro-4,5-dimethoxybenzaldehyde

4-fluoroveratrole

1-(2-fluoro-4,5-dimethoxyphenyl)ethanone

Downstream raw materials:

4,5-dihydroxy-2-fluorobenzoic acid

2,6-difluoroveratraldehyde

5,6-Difluoroveratraldehyde

2,5,6-Trifluoroveratraldehyde

Refernces

• 1、 Nie, Jun-ying,Kirk, Kenneth L.. "Synthesis of fluoro- and polyfluoro-veratraldehydes by electrophilic fluorination". . p. 297 - 302. Retrieved 2007/10/03.