1,8-Naphthyridine-3-carboxylic acid, 7-(2,2-diethoxyethyl)-1-ethyl-1,4-dihydro-4-oxo-6-(phenylmethoxy)-

Base Information

Chemical Name:1,8-Naphthyridine-3-carboxylic acid, 7-(2,2-diethoxyethyl)-1-ethyl-1,4-dihydro-4-oxo-6-(phenylmethoxy)-
CAS No.:79905-34-3
Molecular Formula:C₂₄H₂₈N₂O₆
Molecular Weight:440.496
Hs Code.:

Synonyms:

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Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 7-(2,2-diethoxyethyl)-1-ethyl-1,4-dihydro-4-oxo-6-(phenylmethoxy)-

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Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 7-(2,2-diethoxyethyl)-1-ethyl-1,4-dihydro-4-oxo-6-(phenylmethoxy)-

There total 9 articles about 1,8-Naphthyridine-3-carboxylic acid, 7-(2,2-diethoxyethyl)-1-ethyl-1,4-dihydro-4-oxo-6-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 64-17-5
ethanol

: 79905-33-2
ethyl 6-benzyloxy-7-(2-dimethylaminovinyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

: 79905-34-3
6-benzyloxy-7-(2,2-diethoxyethyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: With hydrogen bromide; for 4h; Heating;
DOI:10.1248/cpb.32.4914

Reference yield:

: 73101-78-7
3-ethoxy-6-nitro-2-picoline

: 79905-34-3
6-benzyloxy-7-(2,2-diethoxyethyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / H₂, 5percent Pd-C / ethanol

2: 85 percent / ethanol / 1 h / Heating

3: 85 percent / 1 h / Heating; Dowtherm

4: 87 percent / K₂CO₃ / dimethylformamide / 1 h / 90 - 100 °C

5: 89 percent / AlCl₃ / CH₂Cl₂ / Ambient temperature

6: 98 percent / K₂CO₃ / N,N-dimethyl-acetamide / 0.5 h / 110 °C

7: 95 percent / hexamethylphosphoric acid triamide / 11 h / 140 °C

8: 67 percent / 47percent HBr / 4 h / Heating

With palladium on activated charcoal; aluminium trichloride; hydrogen bromide; hydrogen; potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.32.4914

Reference yield:

: 6652-01-3
3-ethoxy-2-methyl-pyridine

: 79905-34-3
6-benzyloxy-7-(2,2-diethoxyethyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 91 percent / conc. H₂SO₄, fum. HNO₃ / 0.5 h / 0 - 3 °C

2: 91 percent / H₂, 5percent Pd-C / ethanol

3: 85 percent / ethanol / 1 h / Heating

4: 85 percent / 1 h / Heating; Dowtherm

5: 87 percent / K₂CO₃ / dimethylformamide / 1 h / 90 - 100 °C

6: 89 percent / AlCl₃ / CH₂Cl₂ / Ambient temperature

7: 98 percent / K₂CO₃ / N,N-dimethyl-acetamide / 0.5 h / 110 °C

8: 95 percent / hexamethylphosphoric acid triamide / 11 h / 140 °C

9: 67 percent / 47percent HBr / 4 h / Heating

With palladium on activated charcoal; aluminium trichloride; sulfuric acid; hydrogen bromide; hydrogen; nitric acid; potassium carbonate; In N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.32.4914