6652-01-3

Upstream product

• 1121-25-1 2-methyl-3-pyridinol 
• 74-96-4 ethyl bromide 

Downstream Products

• 73101-78-7 3-ethoxy-6-nitro-2-picoline 
• 73101-90-3 5-ethyl-8-oxo-2,3,5,8-tetrahydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid 
• 73101-87-8 5-ethyl-8-oxo-5,8-dihydrofuro<3,2-b><1,8>naphthyridine-7-carboxylic acid 
• 73101-79-8 6-amino-3-ethoxy-2-picoline 
• 83593-35-5 ethyl 6-benzyloxy-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-7-carboxylate 
• 77016-54-7 3-(6-ethoxy-3-ethoxycarbonyl-4-hydroxy-1,8-naphthyridin-7-yl)acrylic acid 
• 79905-33-2 ethyl 6-benzyloxy-7-(2-dimethylaminovinyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 79905-34-3 6-benzyloxy-7-(2,2-diethoxyethyl)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Condensed 4-aminopyridines with antirheumatic activity

Compounds of formula I STR1 and pharmaceutically acceptable salts thereof in which one of A or B represents N and the other represents N or C--R3 ; R1 represents hydrogen, halo, alkyl, hydroxy, carboxyalkenyl, alkoxycarbonylalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogenated alkyl, carboxy, alkoxycarbonyl, alkanoylamino or carbamoylalkenyl; R2 represents hydrogen, alkyl, halo, alkoxy, hydroxy, alkanoyloxy, or phenoxy; R3 represents hydrogen or alkyl; R4 represents hydrogen, halo, alkoxycarbonyl, cyano, benzyloxycarbonyl, alkanoyl, benzoyl, alkyl, carboxy, alkylthio or carbamoyl; R5 represents hydrogen or alkyl; R9 represents hydrogen or alkyl; R10 represents phenyl, pyridyl or pyrimidinyl substituted by OR6 and optionally further substituted wherein R6 represents hydrogen, alkyl, alkoxycarbonyl or carbamoyl, alicyclic hydrocarbon, phenyl, cycloalkylalkyl, arylalkyl or pyridyl; or when R10 represents phenyl, OR6 represents a monosaccharide group or a disaccharide group; which are antirheumatic agents. Compositions containing these compounds and processes to prepare them are also disclosed.

Amino naphthyridine compounds as anti-rhoumatic agents

This invention relates to compounds of formula I and pharmaceutically acceptable salts thereof STR1 in which R1 represents hydrogen, alkyl, hydroxy, carboxyalkenyl, alkoxycarbonyalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogenated alkyl, carboxy alkoxycarbonyl or alkanoylamino; R2 represents hydrogen, halo, alkoxy, hydroxy, alkanoyloxy, or phenoxy; R3 represents hydrogen or alkyl; R4 represents hydrogen, halo, alkoxycarbonyl, a benzyloxycarbonyl, alkanoyl, benzoyl, carbamoyl, alkyl, carboxy, hydroxyalkyl or alkylthio; R5 represents hydrogen or alkyl; R6 represents hydrogen, alkyl [optionally substituted by one or more of the following: hydroxy, halo or an amino group of formula --NR12 R13 ], a C3-12 alicyclic hydrocarbon group, phenyl, (cycloalkyl)alkyl or benzyl; R7 represents hydrogen, halo, trifluoromethyl, trifluoromethoxy, alkyl, carboxy, or alkoxy; R8 represents hydrogen, halo, trifluoromethyl, trifluoromethoxy, alkyl or alkoxy; and R9 represents hydrogen or alkyl; which are antirheumatic agents. Compositions containing these compounds and processes to make them are also disclosed.