2-Phenylimidazo[2,1-a]isoquinoline

Base Information

• Chemical Name: 2-Phenylimidazo[2,1-a]isoquinoline
• CAS No.: 70845-68-0
• Molecular Formula: C17H12 N2
• Molecular Weight: 244.296
• DSSTox Substance ID: DTXSID30221089
• Nikkaji Number: J61.465C
• Wikidata: Q83098696
• Mol file: 70845-68-0.mol

Synonyms:2-phenylimidazo[2,1-a]isoquinoline;70845-68-0;2-Phenylimidazo(2,1-a)isoquinoline;Imidazo(2,1-a)isoquinoline, 2-phenyl-;BRN 0015101;4-23-00-01938 (Beilstein Handbook Reference);ChemDiv1_004758;Oprea1_600378;Oprea1_622065;SCHEMBL11419932;HMS600I06;DTXSID30221089;CCG-17098;STK081921;AKOS000659470;LS-77902;EU-0072531;AE-641/11430045;SR-01000441897;SR-01000441897-1

Chemical Property of 2-Phenylimidazo[2,1-a]isoquinoline

Chemical Property:

• PSA: 17.30000
• Density: 1.17g/cm³
• LogP: 4.15450
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 244.100048391
• Heavy Atom Count: 19
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

2-PHENYLIMIDAZO(2,1-A)ISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CN3C=CC4=CC=CC=C4C3=N2

Technology Process of 2-Phenylimidazo[2,1-a]isoquinoline

There total 25 articles about 2-Phenylimidazo[2,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

isoquinoline (119-65-3) + α-bromoacetophenone (70-11-1) + benzohydroximoyl chloride (81745-44-0) → 2-Phenyl-imidazo<2,1-a>isochinolin (70845-68-0)

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃; for 3h;

DOI:10.1016/j.tetlet.2013.04.126

Reference yield: 82.0%

isoquinolin-1-ylamine (1532-84-9) + 1-phenyl-2-(p-tolylsulfonyloxy)ethanone (7257-94-5) → 2-Phenyl-imidazo<2,1-a>isochinolin (70845-68-0)

Guidance literature:

With sodium carbonate; N-butylpyridinium tetrafluoroborate; at 20 ℃; for 1h;

Reference yield: 73.0%

isoquinoline (119-65-3) + α-bromoacetophenone (70-11-1) → 2-Phenyl-imidazo<2,1-a>isochinolin (70845-68-0)

Guidance literature:

isoquinoline; α-bromoacetophenone; In dichloromethane; for 3h; Heating;

With ammonium acetate; acetic acid; copper(II) oxide; at 140 - 150 ℃; for 3h;

upstream raw materials:

isoquinolin-1-ylamine

α-bromoacetophenone

2-phenacylisoquinolinium bromide

2-Phenyl-5,6-dihydro-imidazo<2,1-a>isochinolin

Downstream raw materials:

3-Acetyl-2-phenylimidazo<2,1-a>isoquinoline

2-Phenyl-3-(2,2,2-trichloro-1-hydroxyethyl)imidazo<2,1-a>isoquinoline

2-Phenyl-5,6-dihydro-imidazo<2,1-a>isochinolin

3-Formyl-2-phenylimidazo<2,1-a>isoquinoline