Methyl 2-(piperidin-2-yl)acetate

Base Information

• Chemical Name: Methyl 2-(piperidin-2-yl)acetate
• CAS No.: 23692-08-2
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• DSSTox Substance ID: DTXSID10410510
• Nikkaji Number: J1.266.737J
• Mol file: 23692-08-2.mol

Synonyms:methyl 2-(piperidin-2-yl)acetate;23692-08-2;methyl 2-piperidin-2-ylacetate;Methyl piperidin-2-ylacetate;2-Piperidineacetic acid, methyl ester;methyl 2-piperidylacetate;Methyl-2-piperidylacetat;SCHEMBL645913;methyl2-(piperidin-2-yl)acetate;DTXSID10410510;2-(Methoxy-2-oxoethyl)piperidine;KNLRJTRKAHPHEE-UHFFFAOYSA-N;AKOS015998517;MB06952;MB06954;SB41894;piperidin-2-yl-acetic acid methyl ester;BB 0254384;CS-0450015;FT-0733753;EN300-51078;F2158-0908

Chemical Property of Methyl 2-(piperidin-2-yl)acetate

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 157.110278721
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CC1CCCCN1

Technology Process of Methyl 2-(piperidin-2-yl)acetate

There total 15 articles about Methyl 2-(piperidin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-(piperidin-2-yl)acetic acid (19832-04-3) → piperidin-2-yl-acetic acid methyl ester (23692-08-2,171730-95-3)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1021/jo048284j

Reference yield: 96.2%

methyl 2-pyridylacetate (1658-42-0) → piperidin-2-yl-acetic acid methyl ester (23692-08-2,171730-95-3)

Guidance literature:

With platinum (IV) oxide; hydrogen; In methanol; at 25 ℃; for 48h; under 2585.81 Torr;

Reference yield: 86.0%

methyl (1-benzoyloxypiperidin-2-yl)acetate (150931-54-7) → piperidin-2-yl-acetic acid methyl ester (23692-08-2,171730-95-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 0 ℃; for 1h;

DOI:10.1246/bcsj.73.2423

upstream raw materials:

methyl 2-pyridylacetate

methanol

2-pyridineacetic acid

methyl (1-benzoyloxypiperidin-2-yl)acetate

Downstream raw materials:

2-chloro-5-methoxy-4-<5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl>aniline

methyl (R)-(2-piperidino)acetate

(2S)-methoxycarbonylmethylpiperidin

[1-(3-trifluoromethyl-benzenesulfonyl)-piperidin-2-yl]-acetic acid methyl ester