2,3-Dimethyl 5,6-diphenyl-2,3-pyrazinedicarboxylate

Base Information

• Chemical Name: 2,3-Dimethyl 5,6-diphenyl-2,3-pyrazinedicarboxylate
• CAS No.: 80356-81-6
• Molecular Formula: C20H16N2O4
• Molecular Weight: 348.358
• DSSTox Substance ID: DTXSID501222165
• Mol file: 80356-81-6.mol

Synonyms:2,3-Dimethyl 5,6-diphenyl-2,3-pyrazinedicarboxylate;DTXSID501222165;80356-81-6

Chemical Property of 2,3-Dimethyl 5,6-diphenyl-2,3-pyrazinedicarboxylate

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 348.11100700
• Heavy Atom Count: 26
• Complexity: 442

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC(=O)C1=NC(=C(N=C1C(=O)OC)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2,3-Dimethyl 5,6-diphenyl-2,3-pyrazinedicarboxylate

There total 3 articles about 2,3-Dimethyl 5,6-diphenyl-2,3-pyrazinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

methanol (67-56-1) + 2,3-diphenylpyrazine-5,6-dicarboxylic acid (53954-53-3) → dimethyl 5,6-diphenylpyrazine-2,3-dicarboxylate (80356-81-6)

Guidance literature:

With hydrogenchloride; for 0.5h; Heating;

Reference yield: 16.0%

3,4-Diphenyl-1,2,5-selenadiazole (19768-00-4) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 5,6-diphenylpyrazine-2,3-dicarboxylate (80356-81-6)

Guidance literature:

In benzene; at 150 ℃; for 20h;

DOI:10.1246/cl.1991.2043

Reference yield:

5,6-diphenyl-pyrazine-2,3-dicarbonitrile (52197-23-6) → dimethyl 5,6-diphenylpyrazine-2,3-dicarboxylate (80356-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / 30percent KOH, 30percent H₂O₂

2: 96.6 percent / HCl / 0.5 h / Heating

With hydrogenchloride; potassium hydroxide; dihydrogen peroxide;

upstream raw materials:

methanol

2,3-diphenylpyrazine-5,6-dicarboxylic acid

3,4-Diphenyl-1,2,5-selenadiazole

dimethyl acetylenedicarboxylate

Downstream raw materials:

5,6-Diphenyl-pyrazine-2,3-dicarboxylic acid diamide